中性粒细胞淋巴细胞比率,血小板淋巴细胞比率和透析患者抑郁症之间的关系
Duygu Tutan1, Ayşe Erdoğan Kaya2, Bariş Eser3
1Erol Olçok Training and Research Hospital, Department of Internal Medicine, Çorum, Turkey.
Medicine
|September 15, 2023
概括
中性细胞与淋巴细胞比率 (NLR) 可以帮助在透析患者中识别中度至严重的抑郁症. 超过3.26的NLR值表明中度或重度抑郁症的可能性是6.1倍,有助于早期干预.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 慢性病 (CKD) 是一个全球性健康问题,患病率高,相关成本高.
- 抑郁症经常与CKD同时发生,对患者的结果产生负面影响,并增加发病率/死亡率.
- 在透析患者中早期发现抑郁症对于改善健康结果至关重要.
研究的目的:
- 调查中性粒细胞与淋巴细胞比率 (NLR) 和血小板与淋巴细胞比率 (PLR) 与透析患者抑郁症的相关性.
- 评估NLR和PLR作为潜在的生物标志物,用于确定该人群中的抑郁症.
- 确定NLR在检测中度至重度抑郁症时的预测切线值.
主要方法:
- 对71名没有血液学,瘤学或慢性炎症疾病的成年透析患者进行前性研究.
- 收集的数据包括并发症,实验室结果和贝克抑郁症目录 (BDI) 评分.
- 用双项逻辑回归和接收器运行特征 (ROC) 曲线分析来评估NLR和PLR的关联和预测值.
主要成果:
- 超过一半的患者 (52.11%) 呈现中度至重度抑郁症.
- 与最小轻度抑郁症患者相比,中等至重度抑郁症患者的中位数NLR显著更高.
- 多变量分析证实了NLR对抑郁症的预测值,截止值为3.26,显示了88.2%的特异性.
结论:
- 中性粒细胞与淋巴细胞的比率 (NLR) 是一个有价值和实用的生物标志物,用于预测透析患者中度至重度抑郁症.
- 超过3.26的NLR值与中度或重度抑郁症的可能性增加了6.1倍.
- 在接受透析的个体中,NLR可以帮助早期识别和管理抑郁症.
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