健康个体的血清色素表皮衍生因子的性别差异
Cuiliu Li1, Yunna Zhang, Fang Gao
1The Second Department of Endocrinology, Cangzhou Central Hospital, Cangzhou, China.
Medicine
|September 15, 2023
概括
血清色素表皮衍生因子 (PEDF) 显示性变态,年轻男性的水平高于女性. 在女性中,PEDF随着年龄的增长而增加,与代谢因素和雌激素水平相关.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 人体生理学 人体生理学
背景情况:
- 颜料表皮衍生因子 (PEDF) 是一种具有多种生理作用的蛋白质,包括抗血管和抗炎性质.
- 了解其循环水平和潜在的基于性别的差异对于代谢和内分泌研究至关重要.
研究的目的:
- 在健康个体中调查血清PEDF水平的性二态性.
- 确定影响血清PEDF度的因素,特别是与年龄和性别相关的因素.
主要方法:
- 血清PEDF,雌激醇和代谢指数测量了162名健康成年人 (69名男性,93名女性).
- 计算了胰岛素耐药性 (HOMA-IR) 和β细胞功能 (HOMA-β).
- 受试者按年龄分层 (<50岁和≥50岁) 来分析性别差异.
主要成果:
- 总的来说,男性和女性之间没有发现血清PEDF的显著差异.
- 在50岁以下的个体中,男性的PEDF明显高于女性 (P<0.05).
- 在女性中,血清PEDF在50岁以上的女性中明显高于年轻女性 (P<0.05).
- 在女性中,PEDF与BMI,腰围,DBP,葡萄糖,胰岛素,HOMA-β,HOMA-IR,氨基转移酶,三糖醇和雌激素相关.
- 增加的三糖醇,氨基转移酶和减少的雌激素预测女性的PEDF更高.
结论:
- 循环中的PEDF水平表现出性变态,受年龄和潜在的雌激素状态的影响.
- 这些发现突出了PEDF的年龄和性别特异性模式,这与理解代谢健康有关.
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