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结直肠癌治疗中的自然产品和线粒体盟友

Feng Wei¹, Qing Nian², Maoyuan Zhao³

¹Department of Oncology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China; School of Clinical Medicine, Chengdu University of Chinese Medicine, Chengdu 610075, China.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

|September 15, 2023

概括

天然产品通过向线粒体,显示出对抗结直肠癌 (CRC) 的前途. 这些化合物可以通过各种机制诱导癌细胞死亡,为CRC提供潜在的新治疗途径.

科学领域:

生物化学生物化学
在瘤学瘤学.
药理学药理学是指药理学的学科.

背景情况:

大肠直肠癌 (CRC) 是一种广泛的恶性瘤,具有显著的转移潜力.
目前的CRC治疗面临着药物耐药性和不良副作用等挑战.
天然产品正在成为潜在的治疗药物来对抗CRC的进展.

研究的目的:

审查针对线粒体的天然产品对结直肠癌的疗效.
根据其在CRC处理中的作用机制对天然产品进行分类.
探索针对线粒体的天然产品在克服CRC治疗局限性的潜力.

主要方法:

在CNKI,PubMed,Embase和Web of Science数据库中进行全面的文献搜索 (至2023年4月).
对针对线粒体的自然产品进行评估,以对抗CRC.
通过其作用机制对已识别的天然产品进行分类和总结.

主要成果:

自然产品通过线粒体通路诱导CRC细胞的亡,包括呼吸链抑制,ROS调节和线粒体膜潜力的破坏.
机制包括释放亲细胞亡因子,Bcl-2家族调节,酶激活和向线粒体分裂.
特定的天然产品,如迪奥斯基宁,阿洛普林醇和克劳塞尼丁,具有低毒性,高效性和多重向性质.

结论:

自然产品有效地向线粒体,诱导结直肠癌细胞的亡.
这些化合物激活多种类型的线粒体介导的亡信号通路.
针对线粒体的天然产品是推进CRC治疗的有希望的策略.

关键词:

卡斯巴酶依赖的亡.结肠直肠癌是一种癌症.线粒体呼吸链中的线粒体自然产品是天然产品.这就是ROSOS ROS.

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