近期在药品分析中使用静止相合液体染色学方面的进展
Huifeng Liu1, Zhihai Wu2, Jia Chen2
1CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China; Department of Chemistry, College of Sciences, Northeastern University, Shenyang 110819, China.
Journal of chromatography. A
|September 15, 2023
概括
体药物分离对于安全至关重要. 本综述强调了高性能液态染色学 (HPLC) 状静止相 (CSP) 的最新进展,涵盖了糖类,宏循环和多孔有机材料.
科学领域:
- 分析化学 分析化学
- 有机化学 有机化学
- 制药科学 制药科学
背景情况:
- 奇拉性在自然界中普遍存在,不同药物的不同反体表现出不同的生理效应.
- 奇拉化合物的分离对于药物的安全性和有效性至关重要.
- 高性能液态色谱 (HPLC) 是一种用于分离化合物的主要分析技术.
研究的目的:
- 通过HPLC进行药物分析,回顾近期在性静止阶段 (CSP) 的发展.
- 总结各种CSP,包括糖类,宏观循环和多孔有机材料.
- 讨论这些CSP的优点,缺点和未来前景.
主要方法:
- 对HPLC的CSP开发近期进展的文献综述.
- 基于其化学结构的CSP的分类:糖化物,宏循环和多孔有机材料.
- 分析不同CSP的性能,好处和局限性.
主要成果:
- 基于糖的CSP (环极,纤维素,粉素,奇托) 提供了既定的分离能力.
- 宏循环的CSP (糖,柱体[n]arene,聚胺) 呈现出新的结构,用于奇拉识别.
- 多孔有机材料 (MOF,COF,POC) 为高级分离提供可调节的特性和高表面积.
结论:
- 不同的CSP正在不断开发,以满足日益增长的合药物分离和分析需求.
- 每个CSP类别都有独特的优点和缺点,需要对特定应用进行仔细的选择.
- 未来的研究很可能会专注于新型材料和提高性能,以实现更高效和选择性的性分离.
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