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Updated: Jul 16, 2025

Gene Knock-in by CRISPR/Cas9 and Cell Sorting in Macrophage and T Cell Lines
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合成诺基因序列的模块化聚合发现以编程持久的细胞疗法

Franziska Blaeschke1, Yan Yi Chen1, Ryan Apathy1

  • 1Gladstone-UCSF Institute of Genomic Immunology, San Francisco, CA 94158, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

Cell
|September 15, 2023
PubMed
概括

一个新的查平台,ModPoKI,可以快速比较基因修饰,以改善T细胞疗法. 它确定了一种转录因子构造物 (TFAP4),该构造物增强了对抗癌症的CAR-T细胞功能.

关键词:
关于CRISPR的研究嵌合式抗原受体长期刺激人类T细胞免疫疗法其他聚合屏幕合成表面接收器转录系数

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相关概念视频

In-vitro Mutagenesis01:16

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
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