运动和前额叶皮层区域对大脑控制的功能电刺激神经调节的有效性
Rizaldi A Fadli1,2,3, Yuki Yamanouchi1, Lazar I Jovanovic4,5
1Graduate School of Engineering Science, Department of Mechanical Science and Bioengineering, Osaka University, 1-3 Machikaneyama, Toyonaka 560-8531, Japan.
Journal of neural engineering
|September 15, 2023
概括
使用初级运动皮质 (M1) 活动的脑电界面功能电刺激 (BCI-FES) 增强了皮质脊髓刺激能力,表明局部神经调节. 前额叶皮层 (PFC) BCI-FES没有显示类似的效果,表明M1
科学领域:
- 神经科学是一个神经科学.
- 康复工程 康复工程
- 发动机控制器的控制器
背景情况:
- 脑计算机接口 (BCI) 控制的功能电刺激 (FES) 为增强神经康复和运动恢复提供了一个有前途的途径.
- 了解底层的神经调节机制对于优化BCI-FES干预至关重要.
研究的目的:
- 基于BCI-FES的活动来评估初级运动皮层 (M1) 和前额叶皮层 (PFC) 的有效性.
- 通过评估皮质脊髓和皮质刺激性来阐明神经调节机制.
主要方法:
- 12名非残疾参与者在不同的日子接受了25分钟的M1和PFCBCI-FES干预.
- 在M1或PFC中检测到与事件相关的脱同步 (ERD) 触发了手腕伸展肌肉的FES.
- 在干预之前和之后测量了皮层脊髓刺激性,运动图像ERD和静止状态功能连接性.
主要成果:
- 无论是M1和PFC BCI-FES干预都取得了类似的成功率 (~80%).
- M1干预证明了更快的ERD检测,并诱导局部化到M1区域的长期皮质脊髓刺激性变化.
- 无论是M1还是PFCBCI-FES都没有导致皮质刺激度的整体指标发生显著变化.
结论:
- M1 BCI-FES有效调节皮质脊髓刺激能力,这表明局部的神经调节效应可能与直接皮质脊髓投射有关.
- 在ERD检测和FES之间的时间可能会增强Hebbian-like可塑性,同步皮质和感官运动活动.
- 需要进一步的研究来充分了解神经机制,并优化BCI-FES用于运动恢复.
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