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核运输受体KA120调节MAC3的分子凝聚,以协调植物免疫激活

Min Jia¹, Xuanyi Chen², Xuetao Shi³

¹Department of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Innovative Genomics Institute, University of California, Berkeley, Berkeley, CA 94720, USA.

Cell host & microbe

|September 15, 2023

概括

像KA120这样的植物糖可以防止免疫蛋白质的凝聚,而不仅仅是运输. 这种护理活动通过控制病原体防御期间的核蛋白相变调节植物免疫力.

科学领域:

植物分子生物学植物分子生物学
细胞运输机制的细胞运输机制.
植物免疫力植物免疫力

背景情况:

核细胞质运输对于真核细胞来说至关重要,由kariopherins介导.
植物卡里奥菲林及其载荷的作用在很大程度上仍然未知.
KA120是一种卡里奥费林-β,参与抑制阿拉比多普西斯的自身免疫反应.

研究的目的:

在体内识别Arabidopsis karyopherin KA120.20的基质.
阐明KA120在调节核过程中的作用.
了解KA120在植物免疫激活中的作用.

主要方法:

以近距离标记为基础的蛋白质定型被用于识别KA120相互作用蛋白.
评估了蛋白质的核细胞质分布.
分析了蛋白质凝结及其与病原体感染和免疫基因表达的关系.

主要成果:

发现KA120与MOS4关联复合体 (MAC) 的组成部分相互作用,这是一个拼接调节复合体.
KA120不会改变MAC蛋白的核细胞质运输.
KA120 阻止了核中的 MAC 蛋白质的凝结.
病原体感染强烈诱导MAC凝结,激活防御基因表达.
通过阶段过渡,MAC凝结可能会隔离负免疫调节剂.

结论:

植物卡里奥菲林可以拥有非正规的护送活动.
KA120调节了MAC复合体的核凝结.
这种调制对于协调病原体防御期间的植物免疫激活至关重要.

关键词:

卡亚120 卡亚120 卡亚120 卡亚120 是一个在这里,我们可以看到MAC,MAC,MAC.在MAC3MAC3MAC3MAC3MAC3MAC3MAC3 这是MOS4相关复合体.生物分子凝结的生物分子凝结.卡里奥菲林是什么?卡里奥菲林是什么核冷凝物是核冷凝物中的一种.核运输接收器是核运输接收器.植物免疫力植物免疫力

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