辅助生殖中的卵泡液高级糖化终端产品:系统性审查
Fatemeh Roushenas1, Kobra Hamdi2, Farnoosh Jafarpour3
1Department of Reproductive Biology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Clinica chimica acta; international journal of clinical chemistry
|September 15, 2023
概括
毛囊液中的高级糖化终产物 (AGEs) 与辅助生殖技术 (ART) 的成功率降低有关. 评估AGE可能会改善对ART结果的预测.
科学领域:
- 生殖生物学 生殖生物学
- 内分泌学 在内分泌学.
- 生物化学 生物化学
背景情况:
- 卵泡液 (FF) 中的高级糖化终产物 (AGEs) 与卵细胞质量和数量,受精率,胚胎发育和怀孕结果的下降有关.
- 这些关联对于接受辅助生殖技术 (ART) 的妇女尤其重要,包括体外受精 (IVF) 和细胞内精子注射 (ICSI).
研究的目的:
- 系统地审查各种AGE及其对ART结果的影响的文献.
- 研究FF AGEs作为ART成功的预测生物标志物的潜力.
主要方法:
- 进行了系统的文献搜索,以确定检查特定AGE (pentosidine,CML,MG-H1,TAGE,sRAGE) 的研究及其与ART结果的相关性.
- 分析重点是FF AGE水平与关键ART参数之间的关联.
主要成果:
- 总AGE和FF中AGE (sRAGE) 的可溶性受体被发现与卵巢反应,卵泡数,卵细胞检索和成熟 (MII),受精率,胚胎数量和质量以及怀孕成功相关.
- 虽然FF AGEs显示出作为预测生物标志物的潜力,但由于人口异质性和排卵诱导协议的变化,研究结果变得复杂.
结论:
- AGEs在ART结果中起着至关重要的作用.
- 需要进一步的研究来评估血清和FF中的AGE,以提高ART成功的预测.
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