过高甘油三性胰腺炎中的甘油三清除:时间过程及其对管理的影响
1Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut; Departments of Endocrinology and Internal Medicine, Bridgeport Hospital, Yale New Haven Health System, Bridgeport, Connecticut.
概括
过高甘油三性胰腺炎 (HTg) 的管理取决于初始的甘油三水平. 超过4000 mg/dL的水平可能需要更长的治疗才能达到目标甘油三水平低于1000 mg/dL.
科学领域:
- 内分泌学 在内分泌学.
- 胃肠病学 胃肠病学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 过高甘油三性胰腺炎 (HTg) 是一种严重的疾病,需要立即降低甘油三 (Tg).
- 降低Tg的时间过程和影响它的因素尚未完全描述.
研究的目的:
- 分析HTg胰腺炎患者的甘油三降低的时间进程.
- 确定初始Tg水平,原因和干预措施对Tg降低率的影响.
主要方法:
- 在2013-2018年期间,对66名住院患有HTg胰腺炎 (Tg ≥500 mg/dL) 的患者进行了回顾性审查.
- 根据初始Tg值,静脉注射胰岛素的使用以及与乙醇相关的与非乙醇相关的原因评估Tg降低.
主要成果:
- 初始Tg<4000 mg/dL的患者在3天内达到<1000 mg/dL;较高水平的18.8%患者需要5-9天.
- 胰岛素治疗与更长的HTg持续时间相关,而与乙醇相关的原因显示持续时间更短.
- 达到<500 mg/dL或<1000 mg/dL的时间较长,初始Tg>2000 mg/dL.
结论:
- 初始Tg值为4000 mg/dL预测到达<1000 mg/dL (3天内或超过) 的时间.
- 胰岛素对高血糖有好处,但对于单独的乙醇相关的HTg可能不需要.
- 目标Tg水平<1000 mg/dL对于恢复营养摄入比<500 mg/dL更实用.
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