在自身免疫性疾病中静脉血栓栓塞的风险:综合性审查
Danilo Menichelli1, Vito Maria Cormaci2, Silvia Marucci2
1Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy; Department of General Surgery and Surgical Specialty Paride Stefanini, Sapienza University of Rome, 00161 Rome, Italy.
Autoimmunity reviews
|September 15, 2023
概括
自免疫性疾病增加了血栓的风险,特别是静脉血栓栓塞 (VTE). 本综述详细介绍了各种自身免疫性疾病中的VTE风险,并讨论了抗凝剂治疗指南.
科学领域:
- 医学 医学 医学 医学 医学
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
背景情况:
- 自身免疫性疾病的特点是特定的病理生理机制.
- 这些机制有助于增加动脉和静脉血栓形成的风险.
- 静脉血栓塞栓症 (VTE) 的风险受疾病类型,阶段和治疗方法的影响.
研究的目的:
- 审查与增加VTE风险相关的最常见的自身免疫性疾病.
- 提供这些疾病中VTE风险背后的病理生理学的概述.
- 报告目前在VTE预防中使用抗凝剂治疗的适用情况.
主要方法:
- 关于自身免疫性疾病及其与VTE相关性的文献综述.
- 对将自身免疫性疾病与血栓形成联系的病理生理机制的分析.
- 在VTE预防中使用抗凝固剂治疗的当前指导方针的汇编.
主要成果:
- 审查的特定自身免疫性疾病包括抗脂综合征,炎症性肌肉炎,类风湿性关节炎,肉类发病,Sjogren综合征,自身免疫性血液溶解性贫血,全身性红斑狼,全身性硬化,血管炎和炎症性肠病.
- 静脉瘤风险的病理生理学因自身免疫性疾病而异.
- 报告了目前用于初级和二级VTE预防的抗凝固药治疗的指示.
结论:
- 自身免疫性疾病呈现出不同的病理生理路径,从而增加了静脉瘤风险.
- 了解这些机制对于风险分层和风险管理至关重要.
- 抗凝药疗法在患病患者的静脉动脉突发症的初级和二级预防中发挥着关键作用.
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