肠道微生物组与喘和食物过敏儿童的种族有关
Mahboobeh Mahdavinia1, John P Fyolek2, Jialing Jiang2
1Division of Allergy and Immunology, Department of Medicine and Department of Pediatrics, Rush University Medical Center, Chicago, Ill.
The Journal of allergy and clinical immunology
|September 15, 2023
概括
在患有食物过敏 (FA) 的黑人和白人儿童中观察到肠道微生物群的差异. 这些肠道细菌的变异,包括Bacteroides和Bifidobacterium物种,可能会导致FA的黑人儿童喘率更高.
科学领域:
- 微生物组研究的研究.
- 免疫学 免疫学 免疫学
- 儿科过敏症儿童过敏症
背景情况:
- 肠道微生物组的组成与食物过敏 (FA) 和喘等亚托皮性疾病有关.
- 与白人儿童相比,患有FA的黑人儿童患喘的患病率更高.
研究的目的:
- 调查FA儿童肠道微生物群多样性和丰富性的种族差异.
- 为了确定肠道微生物群变异是否与FA儿童的喘有关.
主要方法:
- 枪支基因组测序被用来分析便微生物组样本.
- 对30名黑人和122名白人的肠道微生物群进行了比较,这些儿童患有IgE介导的FA.
主要成果:
- 在种族群体之间发现了特定细菌的相对丰度 (RA) 的显著差异.
- 细菌类和Bifidobacterium物种显示出与种族和喘相关的明显的RA模式.
- 在FA儿童中喘与某些Bifidobacterium和Bacteroides物种的较低的RA以及其他物种的较高的RA有关.
结论:
- 在患有FA的儿童中,肠道微生物群组成存在种族差异.
- 细菌和双细菌物种的变异可能在FA的黑人儿童中观察到的更高的喘率中起作用.
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