血管和淋巴异质性以及牙脉与年龄相关的变化
Haiyang Sun1, Shuhuai Meng1, Zhengyi Xu1
1State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Prosthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Journal of dentistry
|September 15, 2023
概括
年龄降低了牙脉血管,增加了炎症. 这项研究揭示了老年与老鼠和人类有关的血管变化,确定了脉再生和老年牙健康的潜在目标.
科学领域:
- 牙科生物学 牙科生物学
- 血管生物学 血管生物学
- 衰老研究研究 衰老研究
背景情况:
- 牙纸血管化对于牙活力至关重要.
- 牙脉血管结构的与年龄相关的变化尚未得到充分了解.
- 了解这些变化对于纸再生和与年龄有关的牙科疾病至关重要.
研究的目的:
- 为了研究老年相关的血管变化在小鼠和人类的牙纸.
- 为了绘制牙脉血管,牙周细胞和牙周脉矩阵的地图.
- 确定脉再生和与年龄相关的牙疾病的潜在治疗点.
主要方法:
- 修改组织清除和高分辨率的3D成像小鼠和人类牙脉血管系统.
- 隔离和RNA测序年轻和老老老鼠和人类牙纸.
- 对血管亚型,密度,周血管矩阵和炎症标志物的分析.
主要成果:
- 在小鼠牙髓中确定了五种血管亚型,形成了动脉-毛细血管-静脉网络.
- 在老老鼠牙肉质中观察到毛细血管和静脉密度下降.
- 发现周围血管巨细胞和淋巴毛细血管增加,老化的脉中神经和细胞外基质保持不变.
- 观察到人类和小鼠牙脉之间血管图案的相似之处.
- 无论是小鼠还是人类的牙脉都显示出炎症状态.
结论:
- 牙脉血管系统经历了与年龄相关的显著衰退,特别是毛细血管和静脉.
- 炎症状态是老老鼠和人类牙脉的特征.
- TNF和Rap1通路是对抗炎症和促进牙纸中的血管生成的潜在治疗点.
相关概念视频
Overview of the Vascular System
2.8K
The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
2.8K
Tooth Anatomy
536
The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
536
The Effect of Aging on Tissues
2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K
Structure of Blood Vessels
5.2K
Blood is circulated throughout the human body through a network of blood vessels called the circulatory system. This system includes arteries that transport blood from the heart to various body parts. These arterial pathways divide into smaller vessels until they reach the arterioles, which further split into capillaries. It is within these minuscule capillaries that the exchange of nutrients and waste products takes place. After this exchange, the blood is collected by venules, which fuse to...
5.2K
Teeth
482
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
482


