补充蛋白质L-Ficolin和M-Ficolin在轴性脊柱关节炎患者中增加,并在治疗瘤坏死因子抑制剂后减少
Clara Elbæk Mistegaard1, Anne Troldborg2, Annette Hansen3
1C.E. Mistegaard, MD, Department of Rheumatology, Aarhus University Hospital, Aarhus, Department of Clinical Medicine, Aarhus University, Aarhus, Institute of Regional Health Research, University of Southern Denmark, Odense, and Department of Biomedicine, Aarhus University, Aarhus.
The Journal of rheumatology
|September 15, 2023
概括
在轴性脊椎关节炎 (axSpA) 患者中发现L-ficolin和M-ficolin水平升高. 这些水平在阿达利穆马布 (ADA) 治疗后显著下降,这表明补充剂参与axSpA.
科学领域:
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
- 补充系统 补充系统
背景情况:
- 轴性脊柱关节炎 (axSpA) 与补充乳素通路蛋白L-ficolin和H-ficolin的水平升高有关.
- 在腰部疼痛 (LBP) 患者中研究这些生物标志物对于理解axSpA病变的产生至关重要.
研究的目的:
- 评估L-ficolin和M-ficolin在LBP患者的横截面队列中的水平.
- 评估 axSpA 患者在阿达利穆马布 (ADA) 治疗后莱克通路蛋白水平的变化.
主要方法:
- 从两个队列中分析EDTA血样本:横截面LBP队列和经过ADA治疗的纵向axSpA队列.
- 免疫试验用于量化各种莱克通路蛋白的水平,包括MBL,H-ficolin,L-ficolin,M-ficolin,MASPs,MAp19和MAp44.
主要成果:
- 与非特异性LBP的对照组相比,在新诊断的axSpA患者中观察到L-ficolin和M-ficolin的血水平显著增加.
- 在开始ADA治疗后,L-ficolin和M-ficolin水平显著下降.
结论:
- 在新诊断的axSpA患者中,L-ficolin和M-ficolin的水平升高,在接受ADA治疗时降低.
- 这些发现突出了补充系统在axSpA病变发生中的作用,并表明了潜在的治疗点.
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