在极度早产婴儿的NICU人体测量与早期学龄段的大脑发育和语言得分的相关性
Ting Ting Fu1,2, Maria E Barnes-Davis3,4, Hisako Fujiwara4,5
1Division of Neonatology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 7009, Cincinnati, OH, 45229-3026, USA. tingting.fu@cchmc.org.
新生儿重症监护室 (NICU) 在极度早产婴儿的成长会影响大脑发育. 虽然早期的成长与语言相关,但后来的大脑结构关联表明对神经发育的持久影响.
科学领域:
- 神经科学是一个神经科学.
- 发育儿科 发育儿科
- 新生儿科学 新生儿科学
背景情况:
- 新生儿重症监护室 (NICU) 的婴儿生长与大脑发育和早期语言技能有关.
- 新生急症监护室对学龄大脑指标和神经发育的长期影响仍然不清楚.
研究的目的:
- 调查NICU成长与极度早产儿童到学龄儿童的大脑结构/神经发育结果之间的关联.
- 确定早期成长与语言分数的关系是否持续,以及成长是否与皮质指标相关.
主要方法:
- 对42名极度早产婴儿 (怀孕期<28周) 的长度研究.
- 回归分析检查了婴儿生长 (出生,月经后36周) 和神经发育/语言评估 (2岁和4-6岁) 之间的关系.
- 神经成像生物标志物 (T1加权MRI) 在4-6岁时被分析.
主要成果:
- 婴儿出生时的长度和36周月经后的年龄与2岁时的语言分数正相关.
- 没有与4-6岁神经发育评估相关的生长指标.
- 36周月经后的体重和头周长与4-6岁时大脑总体体积增加和全球皮质厚度降低相关. 经过调整后,头周长的关联仍然很重要.
- 右叶皮层厚度与4-6岁的接受性语言有关.
结论:
- 婴儿重症监护室的生长可能会对极度早产儿的大脑发育产生持久的影响.
- 婴儿重症监护室的特定生长参数与儿童时期晚些时候的大脑体积和皮质厚度有关.
- 头周长和右皮层厚度显示出神经发育结果的潜在生物标志物.
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