优化临床营养研究:适应性和务实的试验的作用
Camila E Orsso1, Katherine L Ford1,2, Nicole Kiss3
1Human Nutrition Research Unit, Department of Agricultural, Food & Nutritional Science, University of Alberta, Edmonton, AB, Canada.
European journal of clinical nutrition
|September 15, 2023
概括
随机对照试验 (RCT) 的有效性在现实世界的临床营养研究中存在局限性. 像适应性和实用性试验这样的替代设计可以提高干预的有效性和证据的实施.
科学领域:
- 临床营养研究 临床营养研究
- 基于证据的实践.
- 研究设计研究设计
背景情况:
- 低于最佳的营养状况需要基于证据的建议.
- 有效性随机对照试验 (RCT) 是传统的,但在现实环境中存在局限性.
- 营养干预和临床背景的复杂性挑战了传统的RCT.
研究的目的:
- 探索临床营养研究中替代研究设计的优点和局限性.
- 优化营养干预措施的有效性或有效性.
- 为了弥合有效性-有效性和证据-实践差距.
主要方法:
- 讨论有效性RCT的局限性.
- 对计划修改研究的适应性试验的探索.
- 在临床实践中嵌入实用试验的分析.
主要成果:
- 有效性RCT通常由于固定设计和限制性标准而缺乏外部有效性.
- 适应性试验通过修改来提高疗效评估.
- 实用试验在现实环境中评估有效性,使用以患者为导向的结果和更广泛的资格.
结论:
- 适应性和务实性试验有助于迅速实施基于证据的营养建议.
- 认识到有效性RCT的局限性和替代设计的优势至关重要.
- 这种意识将增加患者从营养建议中获益.
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