布朗的放松震动和打破磁铁氧化物-聚合物纳米复合材料释放货物
Emilia Izak-Nau1, Louisa P Niggemann1,2, Robert Göstl1,2
1DWI-Leibniz Institute for Interactive Materials, Forckenbeckstr. 50, 52056, Aachen, Germany.
Small (Weinheim an der Bergstrasse, Germany)
|September 15, 2023
概括
这项研究引入了一种新的,无热的方法,使用氧化铁纳米颗粒进行分子释放. 通过利用来自布朗放松的机械振动,聚合物 - 药物合物被裂开,释放货物而不产生热量.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
- 生物医学工程 生物医学工程
背景情况:
- 磁纳米粒子 (NP) 用于通过交替磁场 (AMF) 进行远程分子释放.
- 在磁性NP中Néel放松产生热量,限制了它们的应用范围.
- 在AMF下,大于15nm的氧化铁NP经历布朗松 (颠倒和震动).
研究的目的:
- 使用磁纳米粒子开发一种无热分子释放机制.
- 为了利用氧化铁NP的机械运动,用于聚合物-药物合物裂变.
- 扩大磁性NP复合材料在药物输送中的应用.
主要方法:
- 氧化铁纳米粒子 (≈15 nm) 被涂上含有载荷分子 (多克索鲁比,黄素) 的聚合物外.
- 应用了交替磁场 (AMF) 来诱导纳米粒子的布朗松 (震动).
- 机械动导致聚合物链脱落和裂变,释放了货物.
主要成果:
- 成功演示了一种无热货物释放机制.
- 来自布朗松的机械动荡有效地分裂了聚合物链.
- 原型药物分子,多克索鲁比辛和黄素,被释放到溶液中.
结论:
- 这种使用氧化铁NP和布朗松的新型无热释放机制扩大了磁性NP复合材料的应用.
- 机械动方法为产生热量的释放方法提供了替代方案.
- 聚合物功能化磁性NP复合材料显示出对受控,非热分子释放的承诺.
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