维护血液透析患者肠道微生物群的变化及其对患者微炎症状况的影响
Xiaopan Zhang1, Yilin Wang2, Ying Yin2
1Department of Hemodialysis Center, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215000, China. zhang2016xp@163.com.
Cellular and molecular biology (Noisy-le-Grand, France)
|September 16, 2023
概括
患有慢性病 (CKD) 的维持血液透析患者表现出肠道微生物群失调,有益细菌较少,有害细菌较多. 这种不平衡与CKD患者中微炎症标志物增加有关.
科学领域:
- 微生物学 微生物学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 胃肠病学 胃肠病学
背景情况:
- 慢性病 (CKD) 患者接受维护血液透析时经常出现全身并发症.
- 肠道微生物群失调,肠道细菌的不平衡,越来越被认为是导致CKD进展和相关炎症的因素.
- 了解特定的微生物变化及其与炎症的联系对于开发有针对性的干预措施至关重要.
研究的目的:
- 为了研究肠道微生物组合的变化,在维持血液透析的CKD患者中.
- 分析这些肠道微生物变化对患者微炎状态的影响.
- 探索特定肠道细菌和炎症标志物之间的相关性.
主要方法:
- 一项病例对照研究比较了39名维持血液透析CKD患者与40名健康对照.
- 测量肠道微生物群的水平 (Lactobacillus,Bifidobacterium,大肠杆菌,菌).
- 微炎症指标的量化:互白素-6 (IL-6),瘤亡因子α (TNF-α) 和高灵敏性C反应蛋白 (hs-CRP).
- 逐步回归分析以确定微生物群和炎症之间的关系.
主要成果:
- 与对照组相比,CKD患者的乳酸菌和Bifidobacterium水平显著降低 (P<0.05).
- 慢性结核病患者的结核菌和菌水平明显高于对照组 (P<0.05).
- 在CKD患者和对照患者中观察到IL-6,TNF-α和hs-CRP的升高水平 (P<0.05).
- 乳杆菌和Bifidobacterium的水平与炎症标志物有负相关性,而大肠杆菌和肠杆菌的水平与炎症标志物有正相关性.
结论:
- 慢性脏病的维持血液透析与显著的肠道微生物群失生症有关.
- 这种因有益细菌减少和机会性病原体增加而特征的失生症,有助于CKD患者的低级炎症.
- 特定的肠道细菌 (Bifidobacterium, Lactobacillus, Escherichia coli, Enterococcus) 在调节血液透析患者的炎症状态方面发挥着作用.
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