组织分化诱导非蛋白质编码RNA表达与乳腺癌患者的瘤大小之间的关系
Shen Tan1, Aimin Cui2, Nan Bai3
1Department of General Surgery, Beijing Jishuitan Hospital, Beijing100096, China. ts0011222@126.com.
Cellular and molecular biology (Noisy-le-Grand, France)
|September 16, 2023
概括
组织分化诱导非蛋白编码RNA (TINCR) 在乳腺癌组织中减少,使其与非瘤组织区分开来. 在乳腺癌患者中,较低的TINCR水平与较大的瘤和淋巴结转移相关.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 在RNA生物学,RNA生物学.
背景情况:
- 乳腺癌是全球主要的死亡原因,也是女性最常见的恶性瘤.
- 诱导组织分化非蛋白编码RNA (TINCR) 是一种非编码RNA,在癌症发展中具有潜在的作用.
研究的目的:
- 评估TINCR表达水平在侵袭性导管乳腺癌组织与相邻的非瘤组织相比.
- 研究TINCR表达与乳腺癌患者的临床特征之间的相关性.
主要方法:
- 从60名乳腺癌患者的瘤和相邻的非瘤组织中分离RNA.
- 定量逆转录实时PCR (qRT-PCR) 用于量化TINCR表达.
- 配对的t试验和ROC曲线分析用于统计评估和生物标志物评估.
主要成果:
- 与相邻的非瘤组织相比,在乳腺癌瘤组织中观察到TINCR表达显著下降 (P<0.001).
- TINCR表达与瘤大小和淋巴结转移有负相关性.
- 较低的TINCR水平与A组和B组乳腺癌患者相关.
结论:
- 减少TINCR表达有效地将乳腺癌瘤组织与相邻的非瘤组织区分开来.
- TINCR可以作为乳腺癌的潜在生物标志物,降低水平表明更具侵略性的疾病特征.
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