在正常的表皮和牛皮病的损伤性角质细胞中,VEGFRs的表达和功能
Yong Wang1, Yong Yan2, Huiwen Yu3
1School of Medicine, Yichun University, Yichun, 336000, China. PML3515@163.COM.
Cellular and molecular biology (Noisy-le-Grand, France)
|September 16, 2023
概括
血管内皮生长因子受体 (VEGFRs) 在牛皮病皮肤角质细胞中过度表达,离子可能推动这种上调. 这一发现突出了VEGFRs.
科学领域:
- 皮肤病学 皮肤病学
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
背景情况:
- 牛皮是一种慢性炎症性皮肤疾病.
- 血管内皮生长因子受体 (VEGFRs) 在牛皮皮细胞中的作用尚未完全理解.
研究的目的:
- 研究VEGFR-1,VEGFR-2,VEGFR-3在正常表皮和牛皮病变中的表达和功能.
- 为了探索离子对VEGFR表达在牛皮的角质细胞的影响.
主要方法:
- 免疫光分析分析
- 反转录聚合酶连锁反应 (RT-PCR) 是一种
- 西方黑斑是因为西方黑斑.
- 实时定量RT-PCR实时定量
- 从健康和牛皮患者身上切除皮肤组织 (非损伤,邻近和损伤区域).
主要成果:
- VEGFR-1和VEGFR-2在非损伤性皮肤和邻近的牛皮皮肤中显示出强烈的角质细胞标记.
- VEGFR-3的分布与非病变和邻近的牛皮疹皮肤的正常表皮相似,但在所有牛皮疹病变的表皮层中表达.
- VEGFR-1,VEGFR-2和VEGFR-3的mRNA表达从正常皮肤逐渐增加到病变牛皮的皮肤.
- 离子上调 VEGFR mRNA 和蛋白质表达在非损伤性牛皮类角质细胞中.
- 与正常的表皮皮皮质皮质皮质皮质细胞相比,显著增强了VEGFR-1,VEGFR-2,VEGFR-3的mRNA和蛋白质表达在银病变皮质皮质细胞中.
结论:
- 牛皮病变中的角质细胞与正常的表皮角质细胞相比,显示出VEGFR-1,VEGFR-2和VEGFR-3的显著增强表达.
- 在牛皮病变中,VEGF和离子可能会导致VEGFRs过度表达.
- VEGFRs涉及到牛皮的病变发生.
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