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在Covid-19疫苗接种后改变肝功能测试:一项追溯对照组研究

Fernando Ezequiel Jabif¹, Marcelo Gabriel Vallone¹, Vanina Cecilia Stanek²

¹Internal Medicine Section, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Pharmacoepidemiology and drug safety

|September 16, 2023

概括

与流感疫苗接种相比,COVID-19疫苗接种没有增加肝检测变化的风险. 这项研究支持COVID-19疫苗对肝脏健康的安全性.

科学领域:

肝病学肝病学是一种肝病学.
疫苗学疫苗学疫苗学
公共卫生公共卫生

背景情况:

在COVID-19疫苗接种后有事报告的肝损伤.
接种COVID-19疫苗后肝检测变化的发生率和比较风险尚不清楚.

研究的目的:

为了比较COVID-19疫苗接种后新发性肝检测异常的累积发病率.
将这些变化与接受流感疫苗接种的历史对照组进行比较.

主要方法:

进行了一项回顾性队列研究.
接受COVID-19疫苗 (2021年1月至5月) 的成年人与接受流感疫苗 (2019年) 的成年人进行了比较.
分析了肝功能测试,以检测90天内的新发病变化.

主要成果:

该研究包括COVID-19疫苗组的29,798名和流感疫苗组的24,605名.
在90天内,新的肝酶测试变化的累积发病率为COVID-19疫苗的4.7/1000,而流感疫苗的5.1/1000 (p=0.489).
在接种COVID-19疫苗组中观察到两例潜在的免疫媒介性肝损伤.

结论:

在COVID-19和流感疫苗接种者之间没有发现肝检测改变的显著差异.
这些发现表明,COVID-19疫苗对于肝功能是安全的.
虽然在COVID-19疫苗接种后发现了免疫媒介性肝损伤病例,但由于数据不足,因果关系仍未确定.

关键词:

接种Covid-19疫苗的时间改变了肝功能测试的测试.自体免疫性肝炎的发生.化学和药物诱导的肝损伤.不活化的疫苗.流感疫苗和流感疫苗的使用

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