腹腔切除术后的苏加马德克斯和尿:一种倾向匹配的队列研究
Mariana L De Lima Laporta Miranda1, Michelle A Ochs Kinney1, Jamie N Bakkum-Gamez2
1Department of Anesthesiology and Perioperative Medicine, Mayo Clinic School of Graduate Medical Education, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA.
Biomolecules & biomedicine
|September 16, 2023
概括
与neostigmine-glycopyrrolate相比,Sugammadex在切除子宫后降低了术后尿路保留 (POUR) 的风险. 这一发现表明sugammadex可能是妇科手术中神经肌肉阻塞的更安全的逆转剂.
科学领域:
- 麻醉学 麻醉学
- 妇科外科手术 妇科外科
- 药理学 药理学是指药理学的学科.
背景情况:
- 手术后尿 (POUR) 是妇科手术后的一个常见并发症.
- 为逆转神经肌肉阻塞而选择的药物剂可能会影响POUR风险.
研究的目的:
- 调查神经肌肉阻塞逆转剂与子宫切除术后POUR风险之间的关联.
- 为了比较接受sugammadex和neostigmine-glycopyrrolate的患者中POUR的发生率.
主要方法:
- 从1974名经过子宫切除术的成年患者的电子健康记录的倾向调整分析.
- 患者接受了sugammadex或neostigmine-glycopyrrolate,以扭转神经肌肉阻塞.
- POUR被定义为无计划的术后膀再导管.
主要成果:
- 苏加马德克斯与显著降低POUR风险相关 (几率比0.53,P<0.001).
- POUR的发病率为sugammadex的18.3%,与neostigmine-glycopyrrolate的24.8%相比.
- 同时使用甘酸和苏加马德克斯增加了POUR风险.
结论:
- 苏加马德克斯使用与子宫切除术后POUR风险降低有关.
- 忽略经常与尼奥斯蒂格明一起使用的甘酸,可能有助于降低sugammadex的POUR风险.
- 在这种患者群体中,Sugammadex代表了一种潜在的更安全的选择,用于扭转神经肌肉阻塞.
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