运动对超重/肥胖儿童全血转录组概况的影响
Signe Altmäe1,2,3, Abel Plaza-Florido4,5, Francisco J Esteban6
1Department of Biochemistry and Molecular Biology, Faculty of Sciences, University of Granada, Granada, Spain.
概括
超重/肥胖儿童的20周运动计划改变了免疫系统的基因表达. 运动对与免疫反应相关的分子通路的影响在男孩和女孩中不同.
科学领域:
- 儿科健康 儿科健康
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- 对于运动对儿童的分子健康益处的有限理解.
- 儿童超重和肥胖是严重的公共卫生问题.
- 研究儿童肥胖症中运动对基因表达的影响至关重要.
研究的目的:
- 为了检查20周的运动干预对超重/肥胖儿童全血转录组的影响.
- 为了识别运动反应中的性别特异性分子变化.
- 探索免疫相关基因通路的变化.
主要方法:
- 随机对照试验包括24名超重/肥胖儿童 (10.2岁).
- 干预组 (n=10) 接受了20周的运动计划;对照组 (n=14) 没有.
- 使用STRT和GlobinLock技术进行RNA测序 (RNA-seq) 分析的全血转录组.
主要成果:
- 最初,男孩的161个基因和女孩的121个基因在干预后显示出差异性表达 (p<0.05).
- 经过多次校正,两组之间总体基因表达没有显著差异 (FDR>0.05).
- 观察到性别特定的免疫通路丰富:男孩 (抗原处理,T细胞受体),女孩 (Fc epsilon RI信号) (FDR<0.05).
结论:
- 20周的运动干预计划改变了与超重/肥胖儿童免疫过程相关的分子通路.
- 运动引起的免疫系统的分子变化似乎在这个儿科群体中取决于性别.
- 需要进一步的研究来阐明这些分子变化的长期影响.
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