在小鼠耳支细胞中P2Y受体信号的与年龄相关的变化
Sarah A Hool1, Jing-Yi Jeng1, Daniel J Jagger2
1School of Biosciences, University of Sheffield, Sheffield, UK.
The Journal of physiology
|September 16, 2023
概括
老中的支持细胞调节特定的纯能受体 (P2Y2和P2Y4),增强反应. 这种变化可能会保护感官表皮免受与与年龄相关的听力损失相关的进一步损伤.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 神经科学是一个神经科学.
- 细胞生物学 细胞生物学
背景情况:
- 听力依赖于耳毛细胞,由非感官细胞支持,这些细胞对耳平衡至关重要.
- 这些支持细胞在与年龄相关的听力损失中的作用尚不清楚.
- 纯能信号传递对耳发育至关重要,并且随着年龄的增长,各种组织的变化.
研究的目的:
- 为了研究耳支细胞中metabotropic purinergic受体 (P2Y1,P2Y2,P2Y4) 的与年龄相关的变化.
- 了解这些受体变化对老化耳中的信号传递的功能影响.
主要方法:
- 免疫标记和Ca2+成像被用于评估P2Y受体表达和功能.
- 实验对来自小鼠耳的顶端线圈的支细胞进行了实验.
- 在早期产后阶段,成年小鼠和具有不同听力损失概况的老年小鼠之间进行了比较.
主要成果:
- 在出生后的早期阶段,P2Y受体表达和纯能介导的反应下降.
- 与年轻成年人相比,老年耳显示出调节的P2Y受体表达 (P2Y2和P2Y4).
- 年龄较大的小鼠表现出更大的,振荡式对纯能激素的反应,模仿发育阶段.
结论:
- 老中的支持细胞调节P2Y2和P2Y4受体,导致信号的增加.
- 这种上调反映了发育中的纯能反应,并可能作为防止进一步的感觉上皮损伤的保护机制.
- 纯能上调的程度与不同小鼠菌株听力损失的进展相关.
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