长期COVID的可治疗特征
Hayley Lewthwaite1,2, Anthony Byrne3, Bruce Brew4,5,6,7
1Centre of Research Excellence Treatable Traits, College of Health, Medicine, and Wellbeing, University of Newcastle, Newcastle, New South Wales, Australia.
一种个性化医疗方法",可治疗的特征",可以解决复杂的长期COVID症状. 目前的证据支持对胸部和功能问题的炼,但对疲劳,疼痛和睡眠问题需要更多的研究.
科学领域:
- 医学研究 医学研究
- 慢性疾病管理 慢性疾病管理
- 个性化医疗是个性化的医疗.
背景情况:
- 长期COVID (后急性COVID-19后续) 影响8分之一的成年人,呈现复杂的多系统症状.
- 一种适合所有人的治疗方法对于长期COVID的异质性质是不够的.
- "可治疗特征"方法为复杂的慢性疾病提供了个性化医疗.
研究的目的:
- 对长期COVID的"可治疗特征"方法的应用进行审查.
- 为了确定流行长期COVID可治疗的特征和针对性干预的证据.
- 评估有关长期COVID预防和管理策略的当前研究.
主要方法:
- 在22项系统性审查的总体审查中,确定了34种常见的长期COVID症状,分为8个可治疗的特征集群.
- 一项对18项随机对照试验 (RCT) 的系统性审查检查了长期COVID预防和管理的干预措施.
- 数据合成的重点是为特定的长期COVID可治疗特征确定基于证据的策略.
主要成果:
- 34个长期COVID症状被分为8个群体:神经,胸部,心理,疼痛,疲劳,睡眠,功能和其他.
- 有限的证据支持美特福林用于长期COVID预防;需要进一步复制.
- 运动或呼吸肌肉训练对胸部和功能障碍有希望.
结论:
- "可治疗特征"方法是个性化长期COVID护理的可行框架.
- 目前的证据支持针对某些长期COVID集群的具体干预措施,特别是胸部和功能障碍.
- 高质量的RCT对于开发有效治疗疲劳,心理,疼痛和睡眠障碍的治疗至关重要.
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