在养老院居民中使用抗痴呆药物
Brian R Ott1, Carl Hollins2, Jennifer Tjia2
1Department of Neurology, Brown University Warren Alpert Medical School, Providence, RI, USA.
Journal of geriatric psychiatry and neurology
|September 16, 2023
概括
处方抗痴呆药物,如胆酶抑制剂 (ChEIs) 和记忆剂在养老院下降. 在功能依赖居民中,开始治疗的可能性较小,而在住院后停止治疗的可能性更高.
科学领域:
- 老年学是一门学科.
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 抗痴呆症药物为阿尔茨海默病患者提供症状益处.
- 关于在养老院开始和停止使用这些药物存在缺乏共识.
研究的目的:
- 分析胆酶抑制剂 (ChEI) 和痴呆症的新护理院居民中记忆剂使用的趋势.
- 为了确定与这些药物的开始和停止相关的临床因素.
主要方法:
- 从2011年到2018年,对350,197名新入院的痴呆症养老院居民进行了回顾性分析.
- 在养老院入院前后检查的ChEI和记忆剂使用模式.
主要成果:
- 在2011年至2018年期间,抗痴呆症药物的总体使用量下降了.
- 较低的ChEI启动几率与年龄较大,输卵管使用和功能依赖有关.
- 停止ChEIs与并发症,严重行为,认知障碍和高功能依赖性有关.
结论:
- 处方趋势表明,需要进一步研究在养老院开始和停止服用抗痴呆药物的影响.
- 需要更明确的临床指导来为养老院居民做出个性化治疗决策.
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