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皮肤刺痛测试反应强度是否预测过敏性鼻炎的症状严重程度和皮下免疫治疗的疗效?

Xuan Yuan^1,2,3,4, Shaobing Xie^1,2,3,4, Lai Meng^1,2,3,4

¹Department of Otolaryngology Head and Neck Surgery, Xiangya Hospital of Central South University, 87 Xiangya Road, Kaifu District, Changsha, 410008, People's Republic of China.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

|September 16, 2023

概括

过敏原皮肤刺痛测试 (SPT) 的强度不能预测症状严重程度或在过敏性鼻炎 (AR) 中用于粉尘虫免疫治疗的长期成功. 三年后,SPT反应度与治疗结果没有相关性.

科学领域:

过敏和免疫学过敏和免疫学
皮肤病学皮肤病学
耳鼻喉科耳鼻喉科耳鼻喉科

背景情况:

过敏性鼻炎 (AR) 显著影响生活质量.
皮下免疫疗法 (SCIT) 是对AR的长期治疗方法.
皮肤刺伤测试 (SPT) 响应强度是一种常见的诊断措施.

研究的目的:

评估在AR患者中SPT反应强度和症状严重程度之间的关系.
为了确定SPT反应强度是否预测SCIT对粉尘虫过敏的长期疗效.
评估SPT分级作为AR管理的潜在客观标记.

主要方法:

追溯分析了181名AR患者的粉尘虫过敏,经历了3年的SCIT.
根据SPT反应等级 (2,3和4) 将患者分为三组.
在SPT等级组之间进行了基线症状严重程度和长期SCIT疗效的比较.

主要成果:

在SPT等级组中,在基线症状严重程度 (TNSS,SMS,RQLQ,VAS) 中没有发现显著差异.
在3年后评估的SCIT的长期疗效,在SPT等级之间没有统计差异.
吸烟,喘和共同敏感化模式等因素与中度至重度的AR有关,但与SPT强度无关.

结论:

在AR患者中,SPT反应强度不是症状严重程度的可靠指标.
SPT分级并不能预测SCIT对粉尘虫过敏的长期有效性.
当前的SPT分级系统可能不适合客观评估AR严重程度或SCIT结果.

关键词:

过敏性鼻炎是一种过敏性鼻炎.有效性有效性.皮肤刺刺测试试验皮肤刺刺测试皮下免疫疗法是一种皮下免疫疗法.症状严重程度症状严重程度

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