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饮用水中相对较低的化物增加了膝关节关节炎 (KOA) 的风险:中国的一项基于人口的横截面研究

Xinyue Meng¹, Jian Wang¹, Yang Liu¹

¹Key Lab of Etiology and Epidemiology, Education Bureau of Heilongjiang Province & Ministry of Health (23618504), Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin, 150081, Heilongjiang Province, China.

Environmental geochemistry and health

|September 16, 2023

概括

饮用水中的高化物与膝关节骨关节炎风险增加有关. 这种风险特别高于60岁以下的男性,以及那些暴露于高化物水平的肥胖者.

科学领域:

环境健康环境健康
整形外科整形外科整形外科
毒理学毒理学毒理学

背景情况:

众所周知,饮用水中的化物对软骨和骨有毒影响.
骨关节炎 (OA),特别是膝关节骨关节炎 (KOA),是一种常见的退行性关节疾病.
以前的研究表明,化物暴露与骨健康问题之间存在潜在联系.

研究的目的:

调查通过水 (WF) 和尿 (UF) 水平测量化物暴露与膝关节骨关节炎 (KOA) 患病率之间的关联.
确定特定的人口群体,如年龄,性别和肥胖状况,这些人可能更容易受到化物诱导的KOA的影响.

主要方法:

进行了一项涉及1128名参与者的横截面研究.
测量了水化物 (WF) 和尿化物 (UF) 度,以评估化物暴露.
使用后勤回归分析来确定与不同水平的化物暴露相关的KOA风险,并根据相关的共变量进行调整.

主要成果:

增加的化物暴露 (无论是WF和UF) 与更高的KOA风险显著相关.
与最低四分位数 (OR=2.079) 相比,WF暴露的最高四分位数的人患KOA的风险增加了两倍以上.
UF暴露的较高四分位数呈现逐渐增加的KOA风险,最高四分位数呈现近三倍的增加 (OR=2.897).
60岁以下暴露于WF或UF最高四分位数的人群中,KOA的风险明显更高.
增加UF水平与男性的KOA风险更高有关.

结论:

从饮用水中摄入过多的化物是患膝关节关节炎的重要危险因素.
60岁以下的男性和那些肥胖的人似乎更容易患上KOA,当他们接触到更高水平的化物时.

关键词:

横截面研究横截面研究饮用水饮用水饮用水化物的化物.光症是一种光症.膝关节骨关节炎是一种关节炎.尿液尿液尿液

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