严重COVID-19后的两年心肺随访:一项前性研究
Paola Faverio1,2, Giuseppe Paciocco3,4, Elena Tassistro5
1UOC Pneumologia, Respiratory Unit, Fondazione IRCCS San Gerardo dei Tintori, Via Pergolesi 33, 20900, Monza, Italy. paola.faverio@unimib.it.
Internal and emergency medicine
|September 16, 2023
概括
长期的COVID-19幸存者表现出持续的心肺问题. 24个月的肺功能测试和心声回声显示出微妙的右心室功能障碍和气体交换受损,表明需要持续监测.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
背景情况:
- 有广泛的研究存在于短期的COVID-19后果.
- 长期后续研究对于了解持久影响至关重要.
- 心肺并发症需要继续调查.
研究的目的:
- 在SARS-CoV-2肺炎住院后24个月内识别和描述心肺连续症.
- 评估肺功能,运动能力和呼吸障碍.
- 通过心声回声学来评估肺高血压的迹象.
主要方法:
- 对急性呼吸衰竭住院COVID-19患者进行前性观察性队列研究.
- 24个月的随访包括肺功能测试 (PFT),6分钟步行测试和修改的医学研究委员会 (mMRC) 呼吸障碍量表.
- 在肺高血压 (PH) 评估中使用跨胸腔心声学 (TTE) 进行子组分析.
主要成果:
- 26%的患者有轻微的一氧化碳扩散能力 (DLCO) 损伤.
- 34%的人报告持续性呼吸不良.
- 虽然没有发现明显的PH,但20%的患者表现出肺血管阻力升高的迹象,以及对TTE的右心室后负荷.
结论:
- 24个月的随访显示,在严重的COVID-19后,持续的心肺连续症状.
- DLCO和TTE是检测这些长期并发症的敏感工具.
- 大约三分之一的患者出现呼吸障碍,需要采用多学科的管理方法.
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