评估C3抑制对地理缩进展的影响从深度学习的OCT量化:一个分人研究
Dun Jack Fu1, Veronika Lipkova2, Bart Liefers2,3
1NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust-UCL Institute of Ophthalmology, 162 City Rd, London, EC1V 2PD, UK. d.fu@nhs.net.
Ophthalmology and therapy
|September 16, 2023
概括
一种C3抑制剂Pegcetacoplan显著减缓了与年龄相关的黄斑变性干燥患者的地理缩 (GA) 的进展. 与未经治疗的眼睛相比,这种治疗减少了GA的生长,特别是当通过光谱域光学连贯性断层扫描 (SD-OCT) 进行评估时.
科学领域:
- 眼科医生 眼科 眼科
- 视网膜疾病 视网膜疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 地理缩 (GA) 是一种与年龄相关的黄斑变性 (AMD) 的高级形式,导致不可逆转的视力丧失.
- 目前对GA的治疗方法有限,这凸显了需要有效的治疗策略.
- 补充C3抑制剂Pegcetacoplan针对GA进展中涉及的炎症级联的关键组成部分.
研究的目的:
- 评估佩格塞塔科普兰在降低地理缩 (GA) 进展速度方面的疗效.
- 通过光谱域光学连贯性断层扫描 (SD-OCT) 和深度学习量化来评估基塔科普兰的效果.
- 为了比较GA在pegcetacoplan治疗眼睛中的进展与未经治疗的同眼睛在分裂人研究设计中的进展.
主要方法:
- 从第二阶段的FILLY试验 (NCT02503332) 的数据进行了后期分析,该试验涉及144名双边GA患者.
- 患者每月 (PM) 或每隔一个月 (PEOM) 接受 pegcetacoplan 或假注射,在他们的研究眼睛12个月.
- 分析了SD-OCT扫描,以量化视网膜色素上皮质和外视网膜缩 (RORA) 以及其组件的年度变化.
主要成果:
- 与未经治疗的同眼相比,每月佩格塞塔科普兰 (PM) 治疗显著降低了RORA (0.792 mm2对1.13 mm2;P=.003) 和其组件的年增长.
- 类似的,虽然在统计学上不显著,在PEOM治疗和使用 fundus自光 (FAF) 量化GA时观察到的趋势.
- 假药治疗对GA进展没有影响,相关性分析表明PM组中研究和同眼之间GA扩大率的一致性降低.
结论:
- 与未经治疗的同眼相比,Pegcetacoplan治疗显示出地理缩 (GA) 的空间进展显著减少.
- 与FAF相比,Pegcetacoplan对GA的治疗效果在SD-OCT评估时更为明显.
- 这些发现支持pegcetacoplan作为一种治疗方法的潜力,以减缓AMD患者的GA进展.
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