金属混合物与甲状腺功能的关联以及与状态的潜在相互作用:MEWHC的横截面研究的结果
Xiaoting Ge1, Junxiu He2, Sencai Lin2
1Department of Public Health, School of Medicine, Guangxi University of Science and Technology, Liuzhou, 545006, China.
Environmental science and pollution research international
|September 16, 2023
概括
职业接触金属混合物,包括铜和铁,与甲状腺功能的改变有关. 状态可以改变这些效应,强调需要对潜在机制进行进一步研究.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 毒理学 毒理学 毒理学
背景情况:
- 甲状腺激素平衡对于整体健康至关重要.
- 关于金属混合物对甲状腺功能的影响的研究有限,的地位经常被忽视.
研究的目的:
- 在职业队列中调查血液金属度和甲状腺平衡之间的关联.
- 探索状态在这些关系中的潜在改变作用.
主要方法:
- 对来自Manganese-Exposed Workers Healthy Cohort (MEWHC) 的328名工人的横截面研究.
- 测量甲状腺功能参数 (TSH,TT3,FT3,TT4,FT4) 和计算的二氧化酶活性 (GD) 和甲状腺分泌能力 (GT).
- 使用诱导合等离子体质谱法 (ICP-MS) 量化22种血液金属度;统计分析包括LASSO和贝叶斯内核机器回归 (BKMR).
主要成果:
- 在铜和TSH,铁和FT4,和GD,和GD,铜和FT4以及和GD之间发现了显著的关联.
- 在和FT4.4之间观察到一个反转的U形关系.
- 确定了和铜对TSH的协同作用,以及与铜或对TSH的对抗作用.
- 状态改变了和GD之间的关联 (P交互 = 0.026).
结论:
- 暴露于金属混合物可以在职业环境中破坏甲状腺平衡.
- 代奥迪纳斯活性在和GD之间的关联中起作用.
- 需要进一步的研究来验证这些发现,并了解涉及的机制.
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