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关于金属和脂质失调之间的相关性和相互作用的研究:在中国社区居住的老年人中进行的病例对照研究

Zhongyuan Zhang^1,2, Rui Wang^1,2, Pei He^1,2

¹School of Public Health, Ningxia Medical University, No.1160, Shengli Street, Xingqing District, Yinchuan, 750004, People's Republic of China.

Environmental science and pollution research international

|September 16, 2023

概括

这项研究发现,暴露于,和等某些金属与老年人患脱脂症的风险更高有关. 然而,暴露在铁和中显示出对这种疾病的保护作用.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
老年学是一门学科.

背景情况:

之前关于金属暴露和脂质失调的研究缺乏一致性,特别是关于老年人混合金属暴露的研究.
有限的研究已经研究了尿液金属度与社区居住的老年人中脱脂症风险之间的特定关系.

研究的目的:

评估尿液金属度与社区居住的老年人的失脂症风险之间的相关性和相互作用效应.
为了确定与失脂症相关的特定金属及其在老龄化人口中的综合作用.

主要方法:

一个病例对照研究,涉及3384名老年人在阴川.
用感应合等离子体质谱法 (ICP-MS) 测量尿液中的金属含量 (13种金属).
统计分析包括后勤回归,受限立方线 (RCS),LASSO,加权量子素和 (WQS) 和贝叶斯内核机器回归 (BKMR).

主要成果:

尿液中的铁 (Fe) 和 (Se) 与缺脂症风险降低有关 (ORs < 1).
尿液中的 (Zn), (As), (Mo) 和 (Te) 与失脂症的风险增加有关 (ORs > 1).
铁和分别显示了最显著的负面和积极影响. 观察到Te和Se之间存在潜在的积极相互作用.

结论:

混合金属暴露,特别是As,Se,Mo和Te,与老年人患脂质不良的患病率有关.
铁和在混合金属和脂质不良症之间的关联中起着重要作用.
特定金属之间的相互作用,如Te和Se,可能会影响这种人群的脂质失调风险.

关键词:

BKMR BKMR 在线播放案例控制研究研究组合暴露组合暴露组合暴露脱脂血症是什么意思脱脂血症是什么意思相互作用效应的相互作用效应.尿中的金属.

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