农村中国老年人的多元体暴露和认知功能
Lidan Duan1,2, Liqin Su3, Xiaohong He4
1China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, 100050, China.
Biological trace element research
|September 16, 2023
概括
较高的和铜水平与农村老年人的更好的认知功能有关. 还可以减轻的含量.
科学领域:
- 环境健康 环境健康
- 营养流行病学 营养流行病学
- 老年学是一门学科.
背景情况:
- 认知能力下降是老年人群的一个重大问题.
- 环境因素,包括微量元素暴露,可能会影响认知健康.
- 了解多个要素的复杂相互作用对于有针对性的干预至关重要.
研究的目的:
- 研究农村老年人多元元素暴露,特别是 (Se) 和认知功能之间的关联.
- 识别与认知表现相关的特定元素.
- 调查影响认知的元素之间的潜在相互作用.
主要方法:
- 在中国恩施县对416名老年人 (≥60岁) 的横截面研究.
- 测量全血元素度 (Se, Cu, Fe, Zn, Ca, Mg, Cd, As, Pb) 使用诱导联等离子体质谱法 (ICP-MS).
- 通过使用 LASSO,ANCOVA 和 GLM 的九个标准测试和统计分析来评估认知功能.
主要成果:
- (Se),铜 (Cu),铁 (Fe), (Zn), (Ca) 和 (Pb) 独立地与认知有关.
- 较高的Se和Cu水平与更好的认知功能相关.
- 较高的Ca水平与较差的认知功能有关,但Se减轻了这种负面影响.
结论:
- 高和铜水平对老年人的认知功能有益.
- 起着保护作用,抵消对认知的有害影响.
- 这些发现强调了微量元素状态对于维持农村人口老龄化中的认知健康的重要性.
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