COVID-19中的脑病理:临床表现和潜在机制
Zhixing Xu1, Hui Wang2, Siya Jiang3
1First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, 310053, China.
Neuroscience bulletin
|September 16, 2023
概括
脑雾和中风等神经问题发生在超过30%的COVID-19患者身上,类似于Omicron变种. 这篇评论探讨了SARS-CoV-2的情况.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 病毒学 病毒学
背景情况:
- 尽管COVID-19的神经表现不如呼吸系统症状那么常见,但与增加的残疾和死亡率有关.
- 虽然Omicron变种导致的疾病不那么严重,但与之前的菌株相比,神经复杂症的发病率与之前的菌株相似.
- 超过30%的COVID-19患者报告了神经症状,如脑雾,妄想,中风和认知障碍,超过一半的人表现出异常的神经图像.
研究的目的:
- 审查当前关于COVID-19患者神经症状的临床研究结果.
- 将COVID-19的神经症状与流感感染中观察到的神经症状进行比较.
- 阐明SARS-CoV-2入侵和发病机制,为治疗策略提供见解.
主要方法:
- 文献综述总结了COVID-19神经表现的临床发现.
- 在COVID-19和流感之间对神经症状的比较分析.
- 描述SARS-CoV-2的结构,细胞入侵途径和中枢神经系统入侵路径.
主要成果:
- 神经症状在COVID-19中很普遍,影响了30%以上的患者,与不良结果相关.
- 在患有神经症状的患者中,神经影像检测的异常发现很常见.
- 通过特定的途径,SARS-CoV-2侵入中枢神经系统,导致直接损伤和二次病理状况.
结论:
- 了解SARS-CoV-2的神经影响和入侵机制对于有效治疗至关重要.
- 诸如细胞因子风暴,淋巴缺血和高凝血等病理状况加剧了COVID-19中大脑损伤.
- 本综述为预防和治疗与COVID-19相关的大脑损伤提供了见解.
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