相关实验视频
Updated: Jul 16, 2025
08:02
In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
Published on: January 22, 2020
5.5K
补充维生素D可以改善mometasone对过敏性鼻炎的治疗效果
1Respiratory Department, Huichang People's Hospital, Ganzhou, China.
Acta biochimica Polonica
|September 16, 2023
概括
维生素D补充剂增强了对过敏性鼻炎 (AR) 的莫梅松治疗. 这项研究发现,维生素D改善了AR患者的症状和免疫标记,这表明它可以作为辅助疗法使用.
科学领域:
- 免疫学 免疫学 免疫学
- 过敏学 过敏学
- 营养科学 营养科学
背景情况:
- 过敏性鼻炎 (AR) 是一种普遍的疾病,通常用鼻腔皮质类固醇治疗.
- 在AR患者中观察到血清维生素D水平较低.
- 维生素D作为AR辅助疗法的潜力需要进一步研究.
研究的目的:
- 评估维生素D补充剂与mometasone鼻喷剂在治疗中度至重度过敏性鼻炎中的疗效和安全性.
- 评估维生素D对AR患者症状评分,生活质量,T淋巴细胞子集和细胞因子的影响.
主要方法:
- 一项随机对照试验,涉及140名中度至重度AR患者.
- 患者接受了mometasone鼻雾剂;实验组额外接受了维生素D四周.
- 使用总鼻腔症状得分 (TNSS) 和犀牛结膜炎生活质量调查问卷 (RQLQ) 测量有效性.
- 分析的免疫标志物包括T淋巴细胞子集 (CD3+,CD4+,CD8+),IL-10,TNF-α和IFN-γ.
主要成果:
- 两组治疗后的TNSS,CD3+,CD4+,CD4+/CD8+比率,TNF-α和RQLQ得分均显著改善.
- 观察到CD8 +,IFN-γ,IL-10和血清维生素D水平显著增加.
- 实验组 (用维生素D) 与对照组相比,表现出明显更大的改善,除了打喷和眼睛症状.
结论:
- 维生素D补充剂显著增强了梅鼻雾剂在中度至重度过敏性鼻炎患者的治疗效果.
- 维生素D可以作为过敏性鼻炎的有益辅助疗法,改善临床症状和免疫调节.
- 进一步的研究可以探索维生素D在AR管理中的最佳剂量和长期影响.
相关概念视频
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
332
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
332
01:23Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
326
Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
326
01:24Antiasthma Drugs: Methylxanthines
266
Theophylline, a member of the methylxanthine class of bronchodilators, has long been used in asthma management. While its exact mechanism of action is not fully understood, it is believed to have multiple effects on various cellular processes.
Theophylline is thought to inhibit phosphodiesterase enzymes, increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). This rise in cAMP and cGMP concentrations stimulates cardiac function,...
Theophylline is thought to inhibit phosphodiesterase enzymes, increasing intracellular levels of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). This rise in cAMP and cGMP concentrations stimulates cardiac function,...
266
01:23Role of Skin in Vitamin D Synthesis
5.3K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.3K
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
295
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
295
01:20Asthma: Pathogenesis and Management
439
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
439