针对癌症的工程和纳米工程介质干细胞的当前进展:从机制到治疗
Forough Shams1, Bahareh Pourjabbar2, Nader Hashemi3
1Student Research Committee, Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, 1968917313 Tehran, Iran.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
|September 16, 2023
概括
介质细胞干细胞 (MSCs) 显示出癌症治疗的希望,因为它们的瘤定位能力. 基因工程和MSC衍生的外体细胞增强了它们作为向癌症治疗交付工具的潜力.
科学领域:
- 在瘤学瘤学.
- 生物技术是生物技术.
- 细胞疗法细胞疗法
背景情况:
- 介质干细胞 (MSC) 是具有低免疫性和瘤热带迁移的多能干细胞.
- MSCs具有固有的特性,使其适合用于癌症治疗应用.
研究的目的:
- 审查先进的工程和纳米工程技术,以加强基于MSC的癌症治疗.
- 探索MSC衍生的外体在向瘤治疗中的治疗潜力.
主要方法:
- 用MSCs的基因工程来表达瘤抑制剂 (亲亡,抗增殖,抗血管原因子).
- 用纳米粒子药物加载MSC,以提高有效性和外部向.
- 利用MSCs分泌的外体来进行细胞间通信和向瘤细胞输送货物.
主要成果:
- 基因工程MSC可以作为抗癌剂的有效输送工具.
- 载有纳米粒子的MSC和MSC衍生的外体显示出增加治疗效能的潜力.
- 临床前研究表明,在各种恶性瘤中,基于MSC的基因疗法取得了有希望的结果.
结论:
- 先进的工程策略显著提高了MSCs用于癌症治疗的治疗效果.
- 来自MSC的外体体是一种有前途的无细胞治疗方法,用于向癌症治疗.
- 临床试验正在出现,表明基于MSC的疗法从临床前环境发展到临床环境.
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