相关实验视频
Updated: Jul 16, 2025

07:04
Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology
Published on: May 2, 2025
407
癌细胞内在的PD-1:它在恶性进展和免疫治疗中的作用
Muhua Chen1, Lei Bie2, Jieer Ying1
1Department of Hepato-Pancreato-Biliary & Gastric Medical Oncology, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang 310022, China.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
|September 16, 2023
概括
编程细胞死亡蛋白-1 (PD-1) 在癌症中具有双重作用. 癌细胞中的内在PD-1 (iPD-1) 可以抑制或促进瘤生长,影响免疫治疗的有效性.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
背景情况:
- 编程细胞死亡蛋白-1 (PD-1),或CD279,是免疫细胞表达的关键免疫检查点受体.
- PD-1在瘤细胞上与PD-L1/PD-L2结合,促进免疫逃避,是癌症免疫治疗的目标.
- 最近的研究揭示了PD-1的内在变体 (iPD-1) 在癌细胞内表达,这表明它在瘤发生过程中发挥了新的作用.
研究的目的:
- 审查内在PD-1 (iPD-1) 在癌细胞瘤发生和进展中的多方面的作用.
- 阐明 iPD-1 在不同癌症类型中的对比功能背后的分子机制.
- 讨论iPD-1对优化抗PD-1/PD-L1免疫疗法和组合策略的影响.
主要方法:
- 文献综述和对PD-1和iPD-1现有研究的综合.
- 对研究不同癌症类型的iPD-1表达和功能的研究分析.
- 讨论涉及PD-1抑制剂的临床数据和治疗策略.
主要成果:
- iPD-1表现出上下文依赖的作用,抑制非小细胞肺癌和结肠癌中的瘤发生.
- 相反,iPD-1促进黑色素瘤,肝细胞癌,胰腺管腺癌,甲状腺癌,质母细胞瘤和三阴性乳腺癌的瘤发生.
- iPD-1的独特功能可能解释了对抗PD-1疗法的可变反应.
结论:
- 内在PD-1 (iPD-1) 代表了癌症发展的关键因素,根据瘤类型具有相反的影响.
- 了解iPD-1机制对于预测和提高当前免疫疗法的疗效至关重要.
- 准或考虑iPD-1的作用可能会导致改善各种癌症的组合疗法.
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