1型和2型糖尿病患者的维生素D缺乏和并发症的发展:一个队列研究
Ninna Hahn Tougaard1, Tine Willum Hansen1, Peter Rossing2
1Steno Diabetes Center Copenhagen, Borgmester Ib Juuls Vej 83, 2730 Herlev, Denmark.
Journal of diabetes and its complications
|September 16, 2023
概括
维生素D缺乏与1型糖尿病中主要不良心血管事件和心力衰竭的风险增加有关. 它还增加了2型糖尿病中心力衰竭的风险,但不是微血管问题或死亡率.
科学领域:
- 内分泌学 在内分泌学.
- 心脏病学 心脏病学
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 维生素D缺乏症在糖尿病患者中很普遍.
- 维生素D状况与糖尿病并发症之间的关联需要进一步研究.
研究的目的:
- 确定维生素D缺乏是否作为1型和2型糖尿病成年人各种并发症的风险标志物.
- 评估维生素D缺乏和不良结果之间的关系,包括心血管事件,脏疾病和眼睛疾病.
主要方法:
- 一项包括1448名1型糖尿病成年人和770名2型糖尿病成年人的队列研究.
- 维生素D缺乏症被定义为维生素D水平的最低分位数.
- 使用调整后的Cox比例危险模型分析了死亡率,主要不良心血管事件 (MACE),心力衰竭,脏终点和眼睛疾病等结果.
主要成果:
- 维生素D缺乏与1型糖尿病中MACE的风险显著增加有关 (HR:2.6;95% CI:1.3-5.2).
- 在1型 (HR: 16; 95% CI: 4.8-50) 和2型糖尿病 (HR: 2.4; 95% CI: 1.1-5.5) 的维生素D缺乏个体中,观察到心力衰竭的风险更高.
- 维生素D缺乏与微血管并发症或全因死亡率之间没有发现显著的关联.
结论:
- 维生素D缺乏是MACE和1型糖尿病心力衰竭的风险标志物.
- 它也是2型糖尿病中心力衰竭的风险标志物.
- 维生素D缺乏没有被确定为微血管并发症或糖尿病类型中的死亡风险标志物.
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