在第一发精神病患者的认知内个体变异性,认知障碍和心理社会功能
A M Sánchez-Torres1, E García de Jalón2, G J Gil-Berrozpe1
1Department of Psychiatry, Navarra University Hospital, Pamplona, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain.
Psychiatry research
|September 16, 2023
概括
在第一发精神病 (FEP) 患者的认知内个体变异性 (IIV) 与较差的认知功能和社会功能有关. 更高的IIV可能表明认知障碍,即使没有全球缺陷.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 认知心理学 认知心理学
背景情况:
- 认知个体内变化 (IIV) 描述了个体的表现波动.
- 在第一发精神病 (FEP) 患者中对IIV的研究有限.
- 了解FEP中的IIV对于有针对性的干预至关重要.
研究的目的:
- 调查FEP患者IIV和全球认知表现之间的关联.
- 在FEP中探索IIV与心理社会功能之间的关系.
- 确定IIV是否在FEP中作为认知障碍的指标.
主要方法:
- 在24个月的随访计划中评估了103名FEP患者在出院时.
- 使用 MATRICS 认知评估电池 (MCCB) 进行认知功能评估和 IIV 计算.
- 使用社会和职业功能量表 (SOFAS) 和认知评估面试 (CAI-Sp) 进行心理社会功能.
主要成果:
- 在IIV和全球MCCB分数,CAI-Sp和SOFAS之间发现了显著的相关性.
- 与IIV较低的患者相比,IIV高的患者表现出更差的心理社会功能和整体认知表现.
- 与全球认知表现不同的是,IIV与临床特征无关.
结论:
- 在FEP患者中,较高的IIV与较差的认知和心理社会结果有关.
- IIV可以作为FEP认知障碍的敏感标志物,独立于全球认知状态.
- 对IIV的进一步研究可以完善FEP的诊断和治疗策略.
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