微血管光滑肌细胞对血小板衍生的生生长因子和胰岛素样生长因子1表现出不同的表型切换反应
Marisa A Bickel1, David M Sherry2, Elizabeth C Bullen1
1Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, United States of America.
Microvascular research
|September 16, 2023
概括
血小板衍生生长因子 (PDGF) -BB促进血管光滑肌细胞 (VSMC) 的增殖和迁移,而胰岛素样生长因子 (IGF-1) 诱导过度缩小. 了解这些独特的VSMC反应是微血管健康的关键.
科学领域:
- 血管生物学 血管生物学
- 蜂信号传输是如何进行的
- 平滑肌肉细胞生物学
背景情况:
- 血管光滑肌细胞 (VSMC) 的表型切换对于血管形成,稳定性和大脑衰老至关重要.
- 关键调节者包括血小板衍生生长因子 (PDGF) -BB,胰岛素样生长因子 (IGF-1),转化生长因子-β (TGF-β) 和内甲蛋白-1 (ET-1).
- 这些因素在微血管VSMC中的特定作用尚未完全理解.
研究的目的:
- 调查PDGF-BB和IGF-1对微血管VSMC表型切换的不同影响.
- 阐明TGF-β和ET-1调节PDGF-BB诱导的VSMC迁移的机制.
主要方法:
- 使用了初级大鼠微血管VSMCs.
- 用PDGF-BB和IGF-1对细胞进行治疗,以观察表型切换.
- 评估了TGF-β和ET-1对PDGF-BB诱导的迁移的影响.
主要成果:
- PDGF-BB触发了繁殖,领导细胞的形成,并指导了迁移.
- 诱导IGF-1的缩和有限的,非极化细胞迁移.
- TGF-β和ET-1通过抑制极化和领导细胞形成来抑制PDGF-BB诱导的迁移.
- 这两种生长因子都降低了收缩基因的调节;PDGF-BB和IGF-1不同调节了其他基因.
结论:
- PDGF-BB和IGF-1诱导了不同的微血管VSMC表型切换,具有不同的迁移行为.
- IGF-1可能起到慢性血管保护作用,而PDGF-BB则参与诸如新血管化的急性反应.
- 了解这些细微的反应对于管理微血管疾病至关重要.
关键词:
衰老的衰老 衰老的衰老在IGF-1的基础上,IGF-1微血管VSMC的微血管微型船只的使用方法据PDGF的说法,这是一个很好的方法.现象型切换的切换方式索马托热带轴 索马托热带轴血管光滑肌肉细胞细胞更多相关视频
09:06Quantitative Analysis of Cellular Composition in Advanced Atherosclerotic Lesions of Smooth Muscle Cell Lineage-Tracing Mice
Published on: February 20, 2019
8.3K
07:49Molecular Analysis of Endothelial-mesenchymal Transition Induced by Transforming Growth Factor-β Signaling
Published on: August 3, 2018
11.3K
相关概念视频
01:15Receptor Downregulation in MVBs
2.1K
Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
2.1K
01:28Forced Transdifferentiation
1.9K
Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
Artificial...
Artificial...
1.9K