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索马托斯塔丁受体2型和甲状腺刺激激素受体表达在瘤甲状腺瘤:对预后和治疗的影响

Andrea Gillis¹, Rui Zheng-Pywell¹, Chandler McLeod¹

¹Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

|September 16, 2023

概括

甲状腺癌的复发与较高的体静止素受体2型 (SSTR2) 和较低的甲状腺刺激激素受体 (TSHR) 表达有关. 在瘤细胞癌 (OC) 中,这种反向关系可能有助于预后和治疗.

科学领域:

内分泌学在内分泌学.
在瘤学瘤学.
病理学病理学病理学

背景情况:

甲状腺刺激激素受体 (TSHR) 和体静止素受体2型 (SSTR2) 是甲状腺瘤中潜在的治疗标.
它们的表达在原发性甲状腺癌中有所不同,因此需要进一步研究它们在特定亚型中的作用.

研究的目的:

调查SSTR2和TSHR在瘤细胞癌 (OC) 和瘤细胞腺瘤 (OA) 中的差异表达.
确定SSTR2和TSHR表达和临床结果之间的相关性,包括OC中的复发和转移.

主要方法:

在2012年至2019年期间治疗的67种瘤细胞瘤 (15种OA,52种OC) 的回顾性审查.
组织微阵列的构造和SSTR2和TSHR的免疫组织化学染色.
使用基平方和逻辑回归进行统计分析,以评估表达模式和临床变量.

主要成果:

在13%的OA和28%的OC中观察到SSTR2阳性.
在73%的OA和62%的OC中发现了TSHR阳性.
与初级OC相比,复发性/转移性OC显示出较高的SSTR2阳性 (50%vs21%) 和较低的TSHR阳性 (64.3%vs28.9%).
广泛侵入性OC更有可能是SSTR2阳性 (P=.003).
在OC (OR,0.12;P=.006) 中,TSHR和SSTR2阳性之间的反相关性是显著的,但在OA中没有.

结论:

与初级OC相比,复发性和转移性瘤细胞癌呈现出明显的SSTR2-阳性和TSHR-阴性特征.
在OC中SSTR2和TSHR表达之间的反向关系可以作为预后生物标志物.
对这些受体的进一步研究可以为瘤细胞性甲状腺癌的向治疗策略提供信息.

关键词:

免疫组织化学免疫组织化学在瘤细胞癌瘤.索马托斯坦因子受体是什么甲状腺癌是一种癌症.甲状腺刺激激素受体受体

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