时间干扰电刺激对条体中相位多巴胺释放的作用
Youngjong Kwak1, Seokbeen Lim1, Hyun-U Cho1
1Department of Biomedical Engineering, Hanyang University, Seoul, Republic of Korea.
Brain stimulation
|September 16, 2023
概括
在2Hz的时间干扰刺激 (TIS) 抑制了条纹体中多巴胺的释放. 这种神经调节技术显示出影响大脑神经化学的潜力.
科学领域:
- 神经科学是一个神经科学.
- 神经调节是一种神经调节.
- 神经化学 神经化学
背景情况:
- 时间干扰刺激 (TIS) 是一种神经调节技术,用于利用高频电信号刺激大脑深层区域.
- 关于TIS的神经化学影响的研究有限,特别是关于多巴胺通路的研究.
研究的目的:
- 为了研究TIS对中枢前脑束 (MFB) 引起的阶段性多巴胺 (DA) 反应的影响.
- 确定TIS的有效参数,以调节在条纹体 (STr) 中的DA释放.
主要方法:
- 两项实验使用TIS应用于条纹体和皮质进行.
- 使用碳纤维微电极测量MFB引起的相位DA释放.
- 包括节拍频率 (0-130 Hz) 和强度 (0-500 μA) 在内的TIS参数被系统地变化.
主要成果:
- 在2赫兹节拍频率和≥400μA强度的TIS显著减少了MFB引起的阶段性DA释放,在条形体中大约减少了40%.
- 在其他节拍频率或较低的强度下,TIS并没有改变DA释放.
- 皮层应用的2 Hz节拍频率的TIS也减少了DA释放,尽管效果没有持续.
结论:
- 特别是在2赫兹的三角频率下,TIS可以有效地抑制在状体中引起的相位多巴胺释放.
- 纹体应用的TIS和皮质应用的TIS都显示出影响大脑神经化学调节的潜力.
- 这些发现凸显了TIS作为针对性神经化学干预的有希望的工具.
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