动脉瘤上升大动脉的纵向与周边生物机械行为
Benjamin Kramer1, Matthew A Thompson1, Samar A Tarraf2
1Department of Thoracic and Cardiovascular Surgery, Aortic Center, Heart, Vascular & Thoracic Institute, Cleveland Clinic, Cleveland, Ohio.
The Journal of thoracic and cardiovascular surgery
|September 16, 2023
概括
年龄显著影响大动脉组织机制,使非神经瘤组织比神经瘤组织少变形. 了解这些与年龄相关的变化对于治疗上升性大动脉动脉瘤至关重要.
科学领域:
- 生物医学工程 生物医学工程
- 心血管研究研究心血管研究
- 材料科学 材料科学 材料科学
背景情况:
- 大动脉动脉瘤涉及复杂的组织机制.
- 了解组织行为是预测动脉瘤进展和失败的关键.
研究的目的:
- 评估患者和大动脉组织特征如何影响机械性能.
- 为了比较动脉瘤和非动脉瘤组织的纵向和周边机械行为.
主要方法:
- 在134名患者的382个大动脉样本上进行了双轴和单轴测试.
- 梯度增强模型被用来分析机械指标并确定关键预测因素.
- 评估的指标包括过渡应变,触点模块,故障延伸和考希应力.
主要成果:
- 非神经瘤组织的变形性较低,过渡应变压低,而非神经瘤组织的变形性较低.
- 高龄和上升大动脉长度增加是过渡性应变的主要预测因素.
- 纵向标本比周边标本显示较低的故障拉伸和考奇应力,年龄是一个强大的因素.
结论:
- 年龄是大动脉组织机械行为的最重要的预测因素.
- 与动脉瘤组织相比,非动脉瘤组织的变形性降低,即使考虑到年龄.
- 纵向和周边力学上的差异有助于上升大动脉动脉瘤的功能障碍和失败.
相关概念视频
Aneurysm I: Introduction
12
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
12
Eccentric Axial Loading in a Plane of Symmetry
218
Eccentric axial loading occurs when an axial load is applied away from the centroidal axis of a structural member. This scenario is common in engineering, where structural elements may not be directly aligned due to various design or functional requirements.
218
Aneurysm III: Interprofessional Care
9
Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
9
Deformations in a Transverse Cross Section
258
When a material is subjected to uniaxial stress, it elongates or contracts in the direction of the applied force, and also undergoes changes in the perpendicular directions. This behavior is crucial for understanding how materials behave under stress and is governed by mechanical properties such as Poisson's ratio v, which measures the ratio of transverse strain to axial strain.
As the material stretches, it expands or contracts in orthogonal directions to the load. This phenomenon varies...
As the material stretches, it expands or contracts in orthogonal directions to the load. This phenomenon varies...
258
General Case of Eccentric Axial Loading
207
Unsymmetrical bending occurs when the bending moment applied to a structural member does not align with its principal axis. This misalignment leads to complex stress distributions and deflection patterns that differ from symmetrical bending, which are essential for designing structures to withstand different loading conditions.
Consider a member subjected to equal and opposite forces that are applied along a line that does not coincide with the member's neutral axis. In unsymmetrical...
Consider a member subjected to equal and opposite forces that are applied along a line that does not coincide with the member's neutral axis. In unsymmetrical...
207
Deformation in a Circular Shaft
379
One of the distinctive characteristics of circular shafts is their ability to maintain their cross-sectional integrity under torsion. In other words, each cross-section continues to exist as a flat, unaltered entity, simply rotating like a solid, rigid slab. To understand the distribution of shearing stress within such a shaft, consider a cylindrical section inside this circular shaft. This section has a length of L and a radius of R, with one end fixed. The radius of the cylindrical section is...
379


