颗粒物和炎症性皮肤疾病:从流行病学和机理学研究中得出
Ling Chao1, Bin Feng2, Haiyan Liang1
1Henan International Collaborative Laboratory for Health Effects and Intervention of Air Pollution, School of Public Health, Xinxiang Medical University, Xinxiang, Henan Province 453003, China.
The Science of the total environment
|September 16, 2023
概括
暴露于颗粒物 (PM) 与炎症性皮肤疾病有关. 微小可能通过屏障功能障碍,氧化应激和炎症影响皮肤,突出了公共卫生干预的必要性.
科学领域:
- 环境皮肤病学环境皮肤病学
- 毒理学 毒理学 毒理学
- 公共卫生 公共卫生
背景情况:
- 大气颗粒物 (PM) 暴露是心血管和呼吸系统疾病的已知危险因素.
- 新出现的证据表明,PM可以透到皮肤,可能导致炎症,尽管数据仍然有限且相互矛盾.
- 皮肤,作为身体与环境的主要接口,持续暴露于大气污染物.
研究的目的:
- 调查暴露于大气颗粒物 (PM) 和炎症性皮肤疾病的发展之间的联系.
- 综合目前有关各种PM来源 (室外,室内,野火) 对皮肤健康影响的证据.
- 探索将PM暴露与皮肤炎症和疾病联系在一起的潜在机制.
主要方法:
- 系统审查和综合流行病学和毒理学研究.
- 关于怀孕期间的PM暴露及其对后代炎症性皮肤状况的影响的证据分析.
- 检查拟议的潜在生物机制,包括皮肤屏障功能障碍,氧化应激和炎症.
主要成果:
- 流行病学研究主要支持暴露在户外,室内和野火中的PM和炎症性皮肤疾病之间的正相关性.
- 产前PM暴露对后代炎性皮肤疾病的影响显示异质的结果.
- 皮肤屏障功能障碍,氧化应激和炎症被确定为关键机械路径.
结论:
- 暴露于颗粒物 (PM) 与炎症性皮肤疾病有显著的关联.
- 机制包括破坏皮肤屏障功能,诱导氧化应激,促进炎症.
- 公共卫生战略和政府干预对于缓解PM引起的皮肤炎症和疾病至关重要.
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