排便状态与血压水平或血压变化之间的关系
Takuro Kubozono1, Yuichi Akasaki2, Shin Kawasoe2
1Department of Cardiovascular Medicine and Hypertension, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan. kubozono@m.kufm.kagoshima-u.ac.jp.
概括
不经常排便与更高的血压变化有关,这是心血管疾病的关键风险因素. 这项研究发现,在一年内,每日排便没有独立地与血压波动增加有关.
科学领域:
- 心脏病学 心脏病学
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
背景情况:
- 血压变化 (BPV) 是心血管疾病 (CVD) 的独立预测因素.
- 排便状态也与心血管疾病风险独立相关.
- 在BPV和排便状态之间的关系仍然未被充分探索.
研究的目的:
- 为了研究日复一日的血压变化和排便状态之间的关联.
- 要确定排便状态是否是高血压变化的独立预测因素.
主要方法:
- 一组184名参与者在基线和1年后每月至少8天进行家庭血压监测.
- 从家庭血压读数评估的变化系数 (CV) 评估的每日静态血压变化.
- 通过问卷调查确定排便状态.
主要成果:
- 八十九名参与者 (48.4%) 在1年的随访期内 CV 值升高.
- 在没有每日排便组 (72%) 与每日排便组 (42%) 相比,CV升高的参与者比例显著更高 (P=0.001).
- 经过多变量调整后,没有每日排便独立与1年内每日静缩血压变化增加有关 (OR:3.81,95% CI:1.64-8.87,P=0.0019).
结论:
- 没有每日排便是每天血压变化升高的独立风险因素.
- 研究结果表明,通过血压调节,胃肠功能与心血管风险之间存在潜在的联系.
- 需要进一步的研究来阐明这种关联背后的机制.
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