在保加利亚患者中混合 (多个基因型) 杆菌感染
Lyudmila Boyanova1, Liliya Boyanova1, Petyo Hadzhiyski2
1Department of Medical Microbiology, Medical Faculty, Medical University of Sofia, Sofia, Bulgaria.
混合的Helicobacter pylori感染 (MGI) 在保加利亚患者中很常见,影响超过三分之一. 近年来,MGI显著增加,可能与患者因素和COVID-19大流行有关.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 胃肠病学 胃肠病学
背景情况:
- 杆菌是人类重要的病原体.
- 越来越多地识别了多种H. pylori基因型的混合感染 (MGI).
- 了解MGI的患病率和特征对于临床管理至关重要.
研究的目的:
- 确定在布尔加利亚症状患者中混合 (多个基因型) H. pylori 感染 (MGI) 的频率和特定亚型.
- 分析随着时间的推移MGI患病率的趋势.
- 探索与MGI流行相关的潜在因素.
主要方法:
- 分析了155名具有症状的保加利亚患者 (21名儿童,134名成年人) 的H. pylori感染基因型.
- 混合感染亚型的识别和表征,包括双菌株和三菌株感染.
- 2015-2019年和2020-2022年两个时间段之间的MGI患病率的比较.
主要成果:
- 在36.1%的患者中检测到混合H. pylori感染 (MGI).
- 双菌株感染占34.8%,三菌株感染占1.3%.
- MGI患病率显著增加,从26.3% (2015-2019) 增加到51.7% (2020-2022),增加了两倍.
- 发现的最常见的混合亚型是 vacA s1as2 和 vacA s1cs2.
- 在8名患有的患者中没有发现MGI.
结论:
- 混合型H. pylori感染在有症状的保加利亚患者中很普遍,并且近年来呈现出显著的增加.
- 脑膜干预的增加可能受到患者特征和COVID-19流行病相关因素的影响.
- 需要进一步研究混合H. pylori感染的临床意义和演变.
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