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F77抗原是前列腺癌采用T细胞治疗的有希望的标

Payal Grover¹, Selene Nunez-Cruz², John Leferovich²

¹Department of Pathology and Lab Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.

Biochemical and biophysical research communications

|September 17, 2023

概括

研究人员开发了一种针对前列腺癌细胞的F77碳水化合物抗原的新免疫疗法. 这种新型的仿真抗原受体 (CAR) T细胞疗法对治疗前列腺癌和其他表达F77的恶性瘤有前途.

科学领域:

免疫学免疫学免疫学
在瘤学瘤学.
生物技术是生物技术.

背景情况:

化学抗原受体 (CAR) T细胞疗法在血液癌症中取得了成功,但由于目标抗原的有限性,在固体瘤中面临挑战.
前列腺癌是一种显著的固体瘤,需要新的治疗点来进行有效的免疫治疗.
F77碳水化合物抗原存在于雌激素依赖和独立的前列腺癌细胞上,表明其作为通用标的潜力.

研究的目的:

创建和评估一种新型的第二代CAR T细胞疗法,针对前列腺癌细胞的F77碳水化合物抗原.
在体外和体内评估F77特异性CAR T细胞的疗效.

主要方法:

第二代CARs的生成包括CD28和CD137 (4-1BB) 辅刺激域,利用F77特异性抗体的单链可变片段 (scFv).
用编码F77特异性CAR的lentiviral载体转导T细胞.
通过F77特异性CAR T细胞进行细胞因子生产和瘤细胞杀伤的体外评估.
在人前列腺癌异种移植模型 (PC3细胞) 中对F77特异性CAR T细胞疗效的体内评估.

主要成果:

特定于F77的CAR T细胞以F77表达依赖的方式表现出细胞因子的产生和瘤细胞溶解.
在使用用F77特异性CAR T细胞治疗的PC3细胞的人类异种移植模型中观察到前列腺瘤的完全根除.
这项研究证实F77抗原是CAR T细胞免疫治疗的可行标.

结论:

F77碳水化合物抗原是前列腺癌的有希望的免疫治疗点.
特定于F77的CAR T细胞疗法为前列腺癌和其他表达这种抗原的恶性瘤提供了潜在的新治疗策略.
进一步开发F77向免疫疗法是有必要的.

关键词:

在CAR T疗法治疗中.F7777 F7777 F7777 F77 F77 F77 F77 F77 F77 F77 F77 糖甘治疗方法糖甘治疗前列腺癌是什么意思前列腺癌是什么意思

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