双相情感障碍多基因风险与休息状态网络功能连接在患有双相情感障碍和没有双相情感障碍的年轻人中的关联
Xinyue Jiang1, Clement C Zai2, Alysha A Sultan3
1Centre for Youth Bipolar Disorder, Centre for Addiction and Mental Health, Toronto, ON, Canada; Department of Pharmacology & Toxicology, University of Toronto, Toronto, ON, Canada.
概括
双相情感障碍 (BD) 的多基因风险与青春期大脑连接的改变有关. 这种遗传风险得分有助于识别年轻人BD脆弱性的早期神经成像标志物.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
背景情况:
- 青年双极性障碍 (BD) 是一个复杂的疾病,对其遗传和神经生物学基础的理解有限.
- 在BD中观察到休息状态功能连接 (rsFC) 改变,但它们的多基因基础仍然不清楚.
研究的目的:
- 在青少年和年轻成年人网络层面上调查BD (BD-PRS) 的多基因风险和全脑rsFC之间的关联.
- 探索BD-PRS是否与患有BD和没有BD的年轻人的特定大脑网络连接模式有关.
主要方法:
- 利用了99名欧洲血统的年轻人 (年龄在13-20岁,56岁患有BD,43名健康对照人[HC]) 的休息状态fMRI数据.
- 从成年GWAS数据计算BD-PRS,并使用独立组件分析分析rsFC.
- 在总样本中检查了BD-PRS和rsFC之间的关联,并在BD和HC组内单独检查.
主要成果:
- 在总样本中,较高的BD-PRS与较低的突出网络rsFC和较高的前面对面网络rsFC相关.
- 在BD组内,BD-PRS升高与默认模式网络rsFC增加和视觉网络rsFC改变有关.
- 在HC组中,较高的BD-PRS与改变的前端对象网络rsFC有关.
结论:
- 从成年人的遗传数据中获得的BD-PRS与年轻人的大脑网络连接性发生改变有关.
- 研究结果表明,BD-PRS可以识别BD脆弱性的基因影响的神经成像标志物,在疾病过程和健康年轻人中可以在早期检测到.
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