多基因神经病症风险与在更困难的情况下控制效率较低的神经病症有关
Heekyeong Park1, Katherine L Forthman2, Rayus Kuplicki2
1Department of Psychology, University of North Texas at Dallas, TX 75241, USA; Laureate Institute for Brain Research, Tulsa, OK 74136, USA.
Psychiatry research. Neuroimaging
|September 17, 2023
概括
对神经病的遗传倾向会在具有挑战性的控制任务中影响大脑活动. 具有较高遗传风险的个体在面对难以控制的情况时,在特定的大脑区域表现出明显的神经反应.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 行为遗传学 行为遗传学
背景情况:
- 神经症是一种与心理健康问题和难以管理负面事件有关的遗传性特征.
- 了解神经病的遗传基础对于解释它对行为控制的影响至关重要.
研究的目的:
- 调查神经病的遗传倾向与认知控制处理之间的关系.
- 探索神经病的遗传风险如何在不同控制难度的任务中缓和神经反应.
主要方法:
- 利用多基因风险评分 (PRS) 方法来量化神经病的遗传倾向.
- 在406名患者的功能磁共振成像 (fMRI) 中使用停止信号任务.
- 通过改变停止信号异步来操纵控制难度.
主要成果:
- 多基因神经病症风险评分与整体抑制控制能力没有相关性.
- 在困难的控制条件下,高神经症PRS的个体在左背前额皮质,中环和背后带带皮质中表现出增加的活动.
- 这种高度的神经活动在更难控制的条件下特别观察到.
结论:
- 对神经病的遗传倾向会影响神经处理,特别是在具有挑战性的控制环境中.
- 在困难情况下神经反应的改变可能会导致高神经病症患者观察到的负面事件的控制不良.
- 研究结果表明,神经病症的遗传风险与在压力下执行功能的困难之间存在神经生物学联系.
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