在老年人中偏头痛
Sarah Sonja Hugger1, Thien Phu Do2, Håkan Ashina3
1Department of Neurology, Danish Headache Center, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
The Lancet. Neurology
|September 17, 2023
概括
老年人中偏头痛的表现和治疗是复杂的,因为伴随性疾病和非典型症状. 需要对偏头痛缓解和有效治疗这种不断增长的人口进行更多的研究.
科学领域:
- 神经学 神经学
- 老年学是一门学科.
- 临床药理学 临床药理学
背景情况:
- 偏头痛是一种终身的神经系统疾病,在不同年龄段的患病率有所不同.
- 插曲性偏头痛通常会随着年龄的增长而缓解,而慢性偏头痛可能会持续到晚年.
- 老年人 (≥60岁) 在偏头痛诊断和治疗方面存在独特的挑战,原因是并发症和非典型特征.
研究的目的:
- 描述偏头痛在整个生命周期中的临床表现的变化.
- 探索老年人偏头痛缓解的神经生物学基础.
- 解决未满足的临床需求和老年人群中偏头痛管理的证据差距.
主要方法:
- 对老年人偏头痛现有文献的综述.
- 对偏头痛患病率和缓解的流行病学数据的分析.
- 讨论关于偏头痛缓解的神经生物学假设.
- 对老年患者当前的治疗选择及其局限性的评估.
主要成果:
- 偏头痛的表现随着年龄的增长而演变,使老年人诊断复杂化.
- 老年人的并发症可以限制偏头痛的治疗选择.
- 在老年人中偏头痛缓解背后的神经生物学机制尚不清楚.
- 关于新型偏头痛药物在老年人群中的有效性,耐受性和安全性的数据有限.
结论:
- 患有偏头痛的老年人面临着特定的挑战,包括非典型的症状和有限的治疗选择.
- 需要进行纵向研究和有针对性的研究,以了解偏头痛缓解,并为老龄化人口开发有效的治疗方法.
- 目前对于老年人中新型偏头痛治疗的证据往往缺乏,因为它们被排除在临床试验之外.
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