心房动中心声学变化的自然史:纵向改造的对照研究:纵向改造的对照研究
Zak Loring1, Robert M Clare2, Paul Hofmann2
1Division of Cardiology, Department of Medicine, Duke University, Durham, North Carolina; Duke Clinical Research Institute, Durham, North Carolina.
Heart rhythm
|September 17, 2023
概括
心房动 (AF) 与心脏重塑有关,导致左心房扩大和心脏功能障碍在6-24个月内. 了解这种进展有助于个性化患者护理.
科学领域:
- 心脏病学 心脏病学
- 心脏电生理学 心脏电生理学
- 心血管成像 - 心血管成像
背景情况:
- 心房动 (AF) 是一种复杂的疾病,它既可能是心脏重塑的原因,也可能是心脏重塑的结果.
- 在AF患者中,心脏重塑的长期进展尚未完全理解.
研究的目的:
- 调查与AF相关的心声学变化的频率和时间表.
- 在被诊断为AF的患者中描述心脏重塑的自然史.
主要方法:
- 从杜克大学卫生系统 (2005-2018) 的AF患者和对照者的回顾性分析.
- 包括至少有两次跨胸腔心声图 (TTEs) 的患者.
- 根据TTE年,年龄和CHA2DS2-VASc得分,将正常基线TTEs的AF患者与没有AF的对照进行匹配.
主要成果:
- 与对照人群相比,AF患者的左心房扩大,左心室 (LV) 缩和腹功能障碍以及心肌吐率显著更高.
- 这些心声回声学变化在6-12个月内表现为心房扩大,静脉缩功能障碍和心肌吐,在24个月内表现为心心缩功能障碍.
- 在AF和对照组之间没有观察到腹腔大小或所有原因死亡率的显著差异.
结论:
- AF与加速的心脏重塑有关,包括左心房扩大和左心房功能受损,通常在诊断后6-24个月内出现.
- 在AF患者中确定心脏重塑的自然史可以为临床治疗策略和个性化患者管理提供信息.
- 声心图监测对于检测和管理AF相关的心脏改造至关重要.
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